Aliskiren
173334-57-1 Basic informationMore
- Product Name:Aliskiren
- Synonyms: Aliskiren (aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,z-bis(1-methylethyl)benzeneoctanamide CGP 60536 CGP60536B Rasilez SPP 100 Tekturna (aS,S,dS,zS)-d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)--hydroxy-4-methoxy-3-(3-methoxypropoxy)-a,z-bis(1-methylethyl)benzeneoctanamide
- CAS:173334-57-1
- MF:C30H53N3O6
- MW:551.76
- EINECS:605-672-4
- Mol File:173334-57-1.mol
-
USE
Aliskiren is a first-in-class antihypertensive drug that acts by direct
inhibition of renin. It is indicated for oral administration either as monotherapy
or in combination with other antihypertensive agents. Renin catalyzes the
cleavage of angiotensin to form angiotensin I, the first and the rate-limiting step
of the RAAS. The inhibition of renin by aliskiren results in reduced levels of
angiotensin I, angiotensin II, and aldosterone, all of which contribute to the
antihypertensive effect. RAAS modulators are among some of the most
commonly prescribed antihypertensive agents to date.The most common side effect of aliskiren is diarrhea, particularly
with doses higher than 300mg daily. Unlike ACE inhibition, direct inhibition of
renin does not increase bradykinin levels. Elevated bradykinin levels are
thought to be responsible for the angioderma and cough that occur commonly
during treatment with ACE inhibitors.
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Lastest Price from Aliskiren manufacturers
- Aliskiren
-
- US $0.00 /kg
- CAS:173334-57-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20tons
- 2024-04-16
- Aliskiren
-
- US $50.00 /kg
- CAS:173334-57-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100 tons
- 2024-02-27
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- Company Name:Changzhou Red Sun Pharmaceutical Co., Ltd.
- Tel:0519-85223897 13766960291
- Products Intro:Product Name:Aliskiren
CAS:173334-57-1
Purity:99% HPLC Package:25KG - CB Index:58
- Related Information:Catalog(43)
- Company Name:Wuhan Fortuna Chemical Co., Ltd
- Tel:027-027-59207852 13308628970
- Products Intro:Product Name:Aliskiren
CAS:173334-57-1
Purity:99% Package:100g，500g，1kg More... - CB Index:58
- Related Information:Catalog(2894)