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Sunitinib

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557795-19-4 Basic informationMore
USE
Sunitinib is an inhibitor of multiple receptor tyrosine kinases (RTKs) involved in tumor proliferation and angiogenesis, including platelet-derived growth factor receptors (PDGFR), vascular endothelial growth factor receptors (VEGFR), and stem cell factor receptor (KIT). It was launched as an oral treatment for gastrointestinal stromal tumors (GIST) and advanced renal-cell carcinoma (RCC). In vitro, sunitib inhibits VEGFR2, PDGFRα, PDGFRβ, KIT, and FLT3 receptors with IC<sub>50</sub> values in the 4–14nM range, and the ligand-dependent autophosphorylation of VEGFR2 and PDGFRb with IC<sub>50</sub>s of approximately 10 nM. In addition, it inhibits the growth of tumor cells expressing dysregulated target RTKs in vitro and inhibits PDGFRb- and VEGFR2-dependent tumor angiogenesis in vivo. Sunitinib exhibits broad and potent antitumor activity, causing regression in murine models of human epidermal (A431), colon (Colo205 and HT-29), lung (NCI-H226 and H460), breast (MDA-MB-435), prostate (PC3-3M-luc), and renal (786-O) cancers, and suppressing or delaying the growth of many others, including the C6 rat and SF763 T human glioma xenografts and B16 melanoma lung cancer.
Lastest Price from Sunitinib manufacturers
  • Sunitinib
  • US $1.00-0.50/kg
  • CAS:557795-19-4
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 200
  • 2024-03-28
  • Sunitinib
  • US $50.00-2.00/G/Bag
  • CAS:557795-19-4
  • Min. Order: 1G/Bag
  • Purity: 0.99
  • Supply Ability: 100kg
  • 2024-03-26

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  • Company Name:shandong XuanHong Pharmaceutical Technology Co.,Ltd
  • Tel:0531-88801869 15562622698
  • Products Intro:Product Name:Sunitinib
    CAS:557795-19-4
    Purity:98% HPLC Package:1g;5g;10;50g;100g;1kg;10kg More...
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  • Tel:010-82848833 400-666-7788
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  • Company Name:Chembest Research Laboratories Limited
  • Tel:021-20908456
  • Products Intro:Product Name:Sunitinib Base
    CAS:557795-19-4
    Purity:98% Package:100mg;500mg;1g;5g;10g;50g;100g;500g Remarks:C14199 More...
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  • Company Name:Energy Chemical
  • Tel:021-021-58432009 400-005-6266
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    Purity:99% Package:250mg;1g;5g;25g;100mg;10mg;2g;500mg Remarks:NULL More...
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  • Company Name:Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.
  • Tel:21-54820552
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  • Company Name:Suzhou haiyu Biochem Industrial Co., LTD
  • Tel:512-68097639 18013585858
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    Purity:98% Package:25kg Remarks:Cat No.:HYA1469 More...
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