EFONIDIPINE
111011-76-8 Basic informationMore
- Product Name:EFONIDIPINE
- Synonyms: Efonidipine hydrochloride monoethanolate Efonidipine Hydrochloride ethanol (1:1:1) 2-(phenyl(phenylmethyl)amino)ethyleste 3-pyridinecarboxylicacid,1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-1,3,2-dioxa efonidipinehydrochlorideethanolate nz-105 nz105ethanolate r,p-oxide,monohydrochloride
- CAS:111011-76-8
- MF:C34H38N3O7P.C2H6O.ClH
- MW:714.19
- EINECS:
- Mol File:111011-76-8.mol
-
USE
Efonidipine hydrochloride ethanol was first launched in Japan for the treatment of
essential severe and renal hypertension. As the fourteenth dihydropyridine (DHP)
calcium channel blocker to reach the market, it functions by binding to the DHP
receptors on voltage-dependent calcium channels to cause diuretic and natriuretic
actions in patients with essential hypertension. Its vasodilating and calcium
antagonist effects are very slow in onset and long-lasting in all types of
experimentally hypertensive models and the agent is reported to exhibit an improved
side effect profile compared with other drugs of the same class. This may be
explained by the slow and long-lasting inhibition of transmembrane Ca<sup>+2</sup> uptake,
which is accompanied by its very slow binding to and dissociation from the DHP
receptors. A recent study in cholesterol-fed rabbits suggested that efonidipine may
suppress the development of atherosclerosis without affecting the plasma lipids.
Clinical trials for angina, peetoris, and for cerebrovasodilatory disorders have been
reported.
Lastest Price from EFONIDIPINE manufacturers
- Efonidipine
-
- US $0.00 /G
- CAS:111011-76-8
- Min. Order: 1G
- Purity: 98%min
- Supply Ability: 30kg/month
- 2024-12-13
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:Efonidipine hydrochloride Monoethanolate;5-(5,5-DiMethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-3-pyridinecarboxylicacid2-[phenyl(phenylMethyl)aMino]ethylesterhydrochlorideMonoethanolate
CAS:111011-76-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15839)
- Company Name:Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
- Tel:025-66099280 17798518460
- Products Intro:Product Name:Efonidipine Hydrochloride Monoethanolate
CAS:111011-76-8
Purity:95% Package:1g;5g;10g More... - CB Index:55
- Related Information:Catalog(19915)
- Company Name:ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel:18149758185 18149758185
- Products Intro:Product Name:Efonidipine hydrochloride monoethanolate
CAS:111011-76-8
Purity:98% Package:1g;10g;100g - CB Index:58
- Related Information:Catalog(3466)
- Company Name:Taizhou Tongxin Bio-Tech Co., Ltd
- Tel:0523-18601685-898 18652728585
- Products Intro:Product Name:Efonidipine Hydrochloride ethanol (1:1:1)
CAS:111011-76-8
Purity:99% More... - CB Index:60
- Related Information:Catalog(2782)
- Company Name:Watson Biotechnology Co.,Ltd
- Tel:027-59207879 1972026995 18140587686
- Products Intro:Product Name:EFONIDIPINE
CAS:111011-76-8
Purity:99% Package:50g/ - CB Index:55
- Related Information:Catalog(4660)