GDC-0084

• Product Name:GDC-0084
• Synonyms: GDC-0084 5-[8,9-Dihydro-6,6-dimethyl-4-(4-morpholinyl)-6H-[1,4]oxazino[4,3-e]purin-2-yl]-2-pyrimidinamine 5-(6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purin-2-yl)pyrimidin-2-amine 2-Pyrimidinamine, 5-[8,9-dihydro-6,6-dimethyl-4-(4-morpholinyl)-6H-[1,4]oxazino[4,3-e]purin-2-yl]- 5-[6,6-Dimethyl-4-(4-morpholinyl)-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purin-2-yl]-2-pyrimidinamine GDC-0084(RG7666) CS-2290 GDC-0084 (GDC0084
• CAS:1382979-44-3
• MF:C18H22N8O2
• MW:382.42
• EINECS:
• Mol File:1382979-44-3.mol
• 

Stumpf et al. at Genentech Inc. (Roche group) developed an efficient multikilogram process to synthesize the brain penetrant PI3K inhibitor, GDC‐0084, a potential drug candidate for the treatment of several brain cancers. An efficient Suzuki coupling reaction between a chloropyrimidine and an arylboronic ester using a palladium catalyst at low loading was reported. The optimized conditions were demonstrated on 6.75 kg of a chloropyrimidine intermediate, providing 7.49 kg of crude GDC‐0084 (94% yield, 99.4% HPLC purity). Using the commercially available XPhos Pd G2 catalyst, instead of the usual PdCl2(dppf)&middot;CH2Cl2 catalyst, it was possible to reduce the catalyst loading from 2 to 0.5 mol%. A final scavenging/recrystallization combination from Si‐Thiol (a solid‐supported resin) and acetic acid/water provided the crude GDC‐0084 with the required purity and polymorphic form (off‐white solid, 6.41 kg, 83% yield, 99.7% HPLC purity).<br /> <img id="ProductImg1" src="https://www.chemicalbook.com/NewsImg/2019-03-08/20193811585028710.png" /><br /> Genentech&rsquo;s route to GDC‐0084 employing a pivotal Suzuki reaction.

• Company Name:Shanghai SuperLan Chemcial Technique Centre
• Tel:021-2022843681 15618226720
• Products Intro:Product Name:GDC-0084
  CAS:1382979-44-3
  Purity:95% Package:1G,5G,10G,50G,100G,1KG Remarks:G More...
• CB Index:58
• Related Information:Catalog(6870)

• Company Name:Shanghai Lollane Biological Technology Co.,Ltd.
• Tel:021-52996696，15000506266 15000506266
• Products Intro:Product Name:GDC0084
  CAS:1382979-44-3
  Purity:>98% Package:2g Remarks:2g More...
• CB Index:55
• Related Information:Catalog(4121)

• Company Name:Chengdu Celes Technology Co., Ltd
• Tel: 17323066073
• Products Intro:Product Name:GDC-0084
  CAS:1382979-44-3
  Purity:>98% Package:50mg;100mg;1g;5g;10g
• CB Index:58
• Related Information:Catalog(80)

• Company Name:Deyang Sino Biotech. Co., LTD
• Tel:19182167371 19182167371
• Products Intro:Product Name:Paxalisib, GDC-0084, RG7666
  CAS:1382979-44-3
  Purity:98% Package:100mg;1000mg;5000mg
• CB Index:58
• Related Information:Catalog(93)

• Company Name:Dalian Meilun Biotech Co., Ltd.
• Tel:0411-62910999 13889544652
• Products Intro:Product Name:GDC0084
  CAS:1382979-44-3
  Purity:>98%,PI3KmTOR Package:5MG;25MG;
• CB Index:58
• Related Information:Catalog(4647)