Tolcapone
134308-13-7 Basic informationMore
- Product Name:Tolcapone
- Synonyms: TOLOCAPONE 3,4-DIHYDROXYL-5-NITROBENZENYL,4-METHYLBENZENYL KETONE, TALCAPONE Tolcapone (200 mg) Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-Methylphenyl)- (3,4-Dihydroxy-5-nitrophenyl)(p-tolyl)methanone 3,4-DIHYDROXYL-5-NITROBENZYL,4'-METHYLBENZENYL KETONE (3,4-Dihydroxy-5-nitrophenyl) TALCAPONE
- CAS:134308-13-7
- MF:C14H11NO5
- MW:273.24
- EINECS:
- Mol File:134308-13-7.mol
-
USE
Tolcapone, 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone (Tasmar), is a yellow, odorless, nonhygroscopic,crystalline compound (pK<sub>a</sub>＝4.78). Tolcapone israpidly absorbed after oral administration. Tolcapone ishighly bound to plasma albumin (＞98%), and its distributionis therefore restricted. Tolcapone has low first-pass metabolism.It is almost completely metabolized in the liver before excretion, and 60% is excreted by the kidney. The majormetabolite of tolcapone is an inactive glucuronide conjugate.COMT inhibitors increase chronotropic and arrhythmogeniceffects of epinephrine.Tolcapone is indicated as an adjunctto levodopa/carbidopa for the management of signs andsymptoms of PD.
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- Company Name:Shanghai Synmedia Chemical Co., Ltd.
- Tel:021-38681880 13817889927
- Products Intro:Product Name:Tolcapone
CAS:134308-13-7
Purity:98%min Package:1g, 5g, 25g, 100g, 1kg, 25kg More... - CB Index:58
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- Company Name:Shanghai Boyle Chemical Co., Ltd.
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CAS:134308-13-7
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:18210857532 18210857532
- Products Intro:Product Name:Tolcapone
CAS:134308-13-7
Package:100Mg,1g More... - CB Index:76
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- Company Name:Yangzhou Siyu Chemical Co.,Ltd.
- Tel:0514-87325867
- Products Intro:Product Name:3,4-dihydroxy-4'-Methyl-5-nitrobenzophenone
CAS:134308-13-7
More... - CB Index:55
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- Company Name:Chembest Research Laboratories Limited
- Tel:021-20908456
- Products Intro:Product Name:Tolcapone
CAS:134308-13-7
Remarks:C14275 More... - CB Index:61
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- Company Name:Chemsky（shanghai）International Co.,Ltd.
- Tel:021-50135380
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CAS:134308-13-7
Purity:98% More... - CB Index:50
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- Company Name:Sinopharm Chemical Reagent Co,Ltd.
- Tel:86-21-63210123
- Products Intro:Product Name:Tolcapone (200 mg)
CAS:134308-13-7
Package:200 mg More... - CB Index:79
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- Company Name:Tianjin Derchemist Science & Technology Co., Ltd.
- Tel:22-58627059 13920586291
- Products Intro:Product Name:Tolcapone
CAS:134308-13-7
Purity:98% Package:1g；5g；10g；25g；50g；100g；500g；1kg；5kg；10kg；25kg - CB Index:50
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