F-AMidine
877617-45-3 Basic informationMore
- Product Name:F-AMidine
- Synonyms: F-AMidine N-[(1S)-1-(AMinocarbonyl)-4-[(2-fluoro-1-iMinoethyl)aMino]butyl]benzaMide F amidine,Famidine Benzamide, N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-
- CAS:877617-45-3
- MF:C14H19FN4O2
- MW:294.32
- EINECS:
- Mol File:877617-45-3.mol
-
USE
An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:F-AMidine
CAS:877617-45-3
Package:2.5Mg,25Mg More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:Shenzhen Polymeri Biochemical Technology Co., Ltd.
- Tel:+86-400-002-6226
- Products Intro:Product Name:F-AMidine
CAS:877617-45-3
More... - CB Index:58
- Related Information:Catalog(56086)
- Company Name:TargetMol Chemicals Inc.
- Tel: 4008200310
- Products Intro:Product Name:F-amidine
CAS:877617-45-3
Purity:0 Package:25mg/RMB 10600;100mg/RMB 17500;50mg/RMB 13800 - CB Index:58
- Related Information:Catalog(21667)
- Company Name:Shanghai Yubo Biotechnology Co., Ltd.
- Tel:021-51875103 15026509758
- Products Intro:Product Name:F-Amidine
CAS:877617-45-3
- CB Index:58
- Related Information:Catalog(6322)
- Company Name:Shanghai Ziqi Biological Technology Co., Ltd.
- Tel:400-811-9081 13681619662
- Products Intro:Product Name:F-Amidine
CAS:877617-45-3
- CB Index:58
- Related Information:Catalog(6192)
- Company Name:Xiamen Huijia Biological Technology Co., Ltd.
- Tel:0592-6020891
- Products Intro:Product Name:F-Amidine
CAS:877617-45-3
- CB Index:58
- Related Information:Catalog(6979)