WYE-354

• Product Name:WYE-354
• Synonyms: WYE-354 4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid methyl ester methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate WYE-354 (Degrasyn) WYE-354;WYE 354; WYE354 Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pip CS-441 1-Piperidinecarboxylic acid, 4-[6-[4-[(methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester
• CAS:1062169-56-5
• MF:C24H29N7O5
• MW:495.53
• EINECS:
• Mol File:1062169-56-5.mol
• 

A pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.

• Company Name:Shanghai Yu Ben Biotechnology Co., Ltd.
• Tel: 15502154572
• Products Intro:Product Name:WYE-354
  CAS:1062169-56-5
  Purity:98% Package:1g/;5g/
• CB Index:58
• Related Information:Catalog(508)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:WYE 354
  CAS:1062169-56-5
  Package:100Mg,10Mg More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:WYE 354
  CAS:1062169-56-5
  Remarks:C14707 More...
• CB Index:61
• Related Information:Catalog(6005)