Hygrolidin

• Product Name:Hygrolidin
• Synonyms: 1166C Antibiotic 1166C Hygrolidin 2-Butenedioic acid (2E)-, mono[(2R,4R,5S,6R)-6-ethyltetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-2H-pyran-4-yl] ester (9CI)
• CAS:83329-73-1
• MF:C38H58O11
• MW:690.86
• EINECS:
• Mol File:83329-73-1.mol
• 

Hygrolidin is a 16-membered macrocyclic lactone closely related to the bafilomycins, active against Valsa ceratosperma, the pathogen of apple canker disease. Hygrolidin is active against SV40 tumor cells, and inhibits the growth of solid tumor-derived cell lines such as DLD-1 human colon cancer cells with increased cells in G1 and S phases. Hygrolidin decreases cyclin-dependent kinase (cdk) 4, cyclin D and cyclin B, and increases cyclin E and p21 levels. Hygrolidin-induced p21 inhibits cyclin A-cdk2 complex more strongly than cyclin E-cdk2 complex. It also increases p21 mRNA in DLD-1 cells, but not in normal fibroblasts.

• Company Name:Beijing Jin Ming Biotechnology Co., Ltd.
• Tel:010-60605840 18892239720
• Products Intro:Product Name:Hygrolidin
  CAS:83329-73-1
  Package:1mg
• CB Index:58
• Related Information:Catalog(12308)

• Company Name:Lynnchem
• Tel:86-(0)29-85992781 17792393971
• Products Intro:Product Name:Hygrolidin
  CAS:83329-73-1
  Purity:>95% by HPLC Package:1mg;5mg More...
• CB Index:58
• Related Information:Catalog(4587)

• Company Name:Shenzhen Polymeri Biochemical Technology Co., Ltd.
• Tel:+86-400-002-6226 13028896684
• Products Intro:Product Name:Hygrolidin
  CAS:83329-73-1
  More...
• CB Index:58
• Related Information:Catalog(56057)

• Company Name:Zhejiang Huida Biotech Co., LTD
• Tel:0571-89903882 13626641628
• Products Intro:Product Name:Hygrolidin
  CAS:83329-73-1
  Purity:99% HPLC Package:10mg；100mg；1g；10g；100g
• CB Index:58
• Related Information:Catalog(3656)