Blonanserin
132810-10-7 Basic informationMore
- Product Name:Blonanserin
- Synonyms: 6-broMo-4,8-dichloro-5-Methoxyquinoline Blonansarin – Blonanserin, AD-5423, Lonasen Blonanserin-d8 HCl CYCLOOCTA[B]PYRIDINE, 2-(4-ETHYL-1-PIPERAZINYL)-4-(4-FLUOROPHENYL)-5,6,7,8,9,10-HEXAHYDRO- Blonanserin AD 5423 2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
- CAS:132810-10-7
- MF:C23H30FN3
- MW:367.5
- EINECS:
- Mol File:132810-10-7.mol
USE
Blonanserin, a dual antagonist of dopamine D2 and serotonin 5-HT2 receptors, was launched past year in Japan for the oral treatment of psychosis and schizophrenia. It is the latest entry in the class of atypical antipsychotic agents to reach the market. Blonanserin exhibits high affinity for D2 and 5-HT2 receptors (IC50 23.6 and 9.85 nM, respectively). Its affinity for D2 receptors is very close to that of haloperidol and risperidone, whereas the affinity for 5-HT2 receptors is about 7 times higher than that of haloperidol and 10 times lower than that of risperidone.Blonanserin is chemically derived in three steps starting with a polyphosphoric acid mediated condensation reaction of cyclooctanone with 4-fluorobenzoylacetonitrile. The resultant 4-fluorophenylcycloocta[b]pyridin-2-one intermediate is converted to the corresponding 2-chloro derivative by treatment with phosphoryl chloride and subsequently condensed with 1-ethylpiperazine to afford blonanserin.
Lastest Price from Blonanserin manufacturers
- Blonanserin
- US $15.00-10.00/KG
- CAS:132810-10-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 2021-07-13
- Blonanserin
- US $15.00-10.00/KG
- CAS:132810-10-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 2021-07-10
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- Company Name:Zhuhai Yourun Co., Ltd.
- Tel:0756-6811852 13923369215
- Products Intro:Product Name:Blonanserin
CAS:132810-10-7
Purity:99 Package:5KG;1KG More... - CB Index:55
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- Company Name:Hiray Pharma Solutions Ltd.
- Tel: 18371784790
- Products Intro:Product Name:Blonanserin
CAS:132810-10-7
Purity:>=99.8% Package:2kg - CB Index:58
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- Company Name:SiChuang NanBu Honesty Technology Co., Ltd.
- Tel:0838-5675166 15883665058
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Purity:>=99.5% More... - CB Index:55
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Blonanserin, 99.5%, a D2/5-HT2 receptor antagonist
CAS:132810-10-7
Purity:99.5% Package:1G;250MG;5G More... - CB Index:76
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- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
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CAS:132810-10-7
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- Company Name:TCI (Shanghai) Development Co., Ltd.
- Tel:021-67121386
- Products Intro:Product Name:Blonanserin
CAS:132810-10-7
Purity:98.0 Package:780RMB/25MG More... - CB Index:81
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