Anagrelide hydrochloride
58579-51-4 Basic informationMore
- Product Name:Anagrelide hydrochloride
- Synonyms: 1-b)quinazolin-2(3h)-one,6,7-dichloro-1,5-dihydro-imidazo(monohydrochlorid 6,7-DICHLORO-1,5-DIHYDROIMIDAZO[2,1-B]QUINAZOLIN-2(3H)-ONE MONOHYDROCHLORIDE ANAGRELIDE HYDROCHLORIDE BL-4162A BMY-26538-01 AnagrelideHclC10H7C12N30.HC1 Agryline,HCl BL-4162A, BMY-26538-01, Agrylin,
- CAS:58579-51-4
- MF:C10H8Cl3N3O
- MW:292.55
- EINECS:680-360-9
- Mol File:58579-51-4.mol
-
USE
<p>Anagrelide hydrochloride was launched in the US for thrombocytosis (essential or associated with chronic myelogenous leukemia). The imidazoquinazoline derivative can be prepared from 2,5,6-trichloro-3,4-dihydropyrimidine via alkylation with ethyl bromoacetate followed by heating with ethanolic ammonia or treatment of N-(a-amino- 5,6-dichlorobenzyl)glycine ethyl ester with cyanogen bromide. As a result of its anti-cAMP phosphodiesterase (PDE Ⅲ) activity, Anagrelide hydrochloride was initially tested as a platelet aggregation inhibitor. However it was found that at much lower concentrations it became thrombocytopenic. While the mechanism is not fully understood, it did not shorten platelet survival nor inhibit the formation of colony-forming unitsmegakaryocytes (CFU-M) but primarily interfered with the maturation of megakaryocytes (reduction in size with altered ploidy). It did decrease peripheral vascular resistance and had a positive inotropic effect.</p>
Lastest Price from Anagrelide hydrochloride manufacturers
- Anagrelide Hydrochloride
-
- US $0.00 /g
- CAS:58579-51-4
- Min. Order: 1g
- Purity: More Than 99%
- Supply Ability: 100kg/Month
- 2024-08-05
- Anagrelide hydrochloride
-
- US $0.00 /Kg/Drum
- CAS:58579-51-4
- Min. Order: 25Kg/Drum
- Purity: 98%
- Supply Ability: 1ton
- 2019-10-30
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- Company Name:Shanghai jerryxing Biomedical Technology Co., Ltd
- Tel: 17721492509
- Products Intro:Product Name:Anagrelide hydrochloride
CAS:58579-51-4
Purity:98% HPLC Package:500mg;1g;10g;100g;1kg - CB Index:58
- Related Information:Catalog(5347)
- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Anagrelide Hydrochloride
CAS:58579-51-4
Package:100Mg,10Mg,50Mg More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:Anagrelide hydrochloride;6,7-Dichloro-1,5-dihydroiMidazo[2,1-b]quinazolin-2(3H)-onehydrochloride
CAS:58579-51-4
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15848)
- Company Name:Chembest Research Laboratories Limited
- Tel:021-20908456
- Products Intro:Product Name:Anagrelide hydrochloride(BL 4162A)
CAS:58579-51-4
Remarks:C13294 More... - CB Index:61
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- Company Name:Hangzhou Yuhao Chemical Technology Co., Ltd
- Tel:0571-82693216
- Products Intro:Product Name:Anagrelide hydrochloride
CAS:58579-51-4
More... - CB Index:52
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- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:Anagrelide hydrochloride
CAS:58579-51-4
Purity:>98%,BR Package:50MG Remarks:MB1881 More... - CB Index:58
- Related Information:Catalog(4667)