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Valacyclovir hydrochloride

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124832-27-5 Basic informationMore
USE
<p>Valacyclovir hydrochloride, an orally active L-valyl ester of the potent antiviral agent aciclovir, was launched in 1995 in the United Kingdom for the treatment of herpes simplex virus (HSV) infections of the skin and mucous membranes, including initial and recurrent genital herpes. As a prodrug, valaciclovir has an improved pharmacokinetic profile to aciclovir. It is rapidly absorbed after oral administration and extensively converted to aciclovir via first-pass metabolism to achieve plasma levels of aciclovir comparable to those seen with aciclovir via i.v. route. Valacyclovir is then activated selectively in virus-infected cells by viral thymidine kinase to form aciclovir triphosphate in a stepwise fashion. This active species inhibits viral DNA polymerase via irreversible binding to the active site of the enzyme. Once aciclovir is incorporated into the elongating viral DNA, it terminates replication of the viral DNA strand, an antiviral mechanism unique to aciclovir. Valacyclovir is reportedly in clinical trials for the suppression of cytomegalovirus infection and disease in renal transplant patients.</p>
Lastest Price from Valacyclovir hydrochloride manufacturers
  • Valacyclovir HCl
  • US $180.00 /kg
  • CAS:124832-27-5
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 20ton
  • 2024-12-20

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  • Company Name:Wuhan Runzeweiye Technology Co., Ltd.
  • Tel:15172337137 15172337137
  • Products Intro:Product Name:Valaciclovir HCl
    CAS:124832-27-5
    Purity:99%
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    Purity:99% HPLC Package:1KG;5KG;10KG
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  • Tel:010-82848833 400-666-7788
  • Products Intro:Product Name:Valacyclovir hydrochloride, 98%, HSV antagonist
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    Purity:98% Package:250MG;50MG More...
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  • Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
  • Tel:021-61259108 18621169109
  • Products Intro:Product Name:Valacyclovir Hydrochloride Hydrate
    CAS:124832-27-5
    Purity:>97.0%(LC)(N) Package:100Mg;1g Remarks:V0111 More...
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  • Company Name:Chembest Research Laboratories Limited
  • Tel:+86-21-20908456
  • Products Intro:Product Name:Valacyclovir Hydrochloride
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    Remarks:C14309 More...
  • CB Index:61
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  • Company Name:TCI (Shanghai) Development Co., Ltd.
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  • Products Intro:Product Name:Valacyclovir Hydrochloride Hydrate
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    Purity:97.0% LC&N Package:100MG,1G More...
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