Doxercalciferol

• Product Name:Doxercalciferol
• Synonyms: 1-alpha-hydroxyergocalciferol 1alpha-hydroxyergocalciferol 1-alpha-hydroxyvitamind2 1-hydroxyergocalciferol 1ALPHA-OH-D2 7,10(19),22-tetraene-1,3-diol,(1-alpha,3-beta,5z,7e,22e)-10-secoergosta-5 VITAMIN D2, 1ALPHA-HYDROXY- Vitamin D2, 1a-Hydroxy-
• CAS:54573-75-0
• MF:C28H44O2
• MW:412.65
• EINECS:
• Mol File:54573-75-0.mol
• 

Doxercalciferol is a synthetic vitamin D2 analog introduced in the US as Hectorol for the treatment of secondary hyperparathyroidism (SHPT) in patients with end-stage renal failure. It is actually 1-alpha-hydroxyvitamin D2 (one-alpha- D2) and can be synthesized by direct hydroxylation of vitamin D2 tosylate or in 5 steps from ergosterol. Doxercalciferol itself is inactive until metabolized by the liver into active 1,24-dihydroxyvitamin D2, showing a pharmacokinetic profile similar to calcitriol. During placebo-controlled clinical trials, patients with moderate to severe SHPT were treated with 1-alpha-D2 (10 μg doses) for 16 to 24 weeks; in 9 patients out of 10, blood levels of parathyroid hormone were considerably reduced, so maintaining a good control of the parathyroid hyperplasia. Moreover, only a moderate tendency to raise calcium and phosphate was observed. Doxercalciferol is orally-active and less toxic than other vitamin D analogs like alfacalcidol; it shows differentially controlled effects and has an improved safety profile compared to calcitriol.Doxercalciferol is a synthetic vitamin D2 analog introduced in the US as Hectorol for the treatment of secondary hyperparathyroidism (SHPT) in patients with end-stage renal failure. It is actually 1-alpha-hydroxyvitamin D2 (one-alpha- D2) and can be synthesized by direct hydroxylation of vitamin D2 tosylate or in 5 steps from ergosterol. Doxercalciferol itself is inactive until metabolized by the liver into active 1,24-dihydroxyvitamin D2, showing a pharmacokinetic profile similar to calcitriol. During placebo-controlled clinical trials, patients with moderate to severe SHPT were treated with 1-alpha-D2 (10 μg doses) for 16 to 24 weeks; in 9 patients out of 10, blood levels of parathyroid hormone were considerably reduced, so maintaining a good control of the parathyroid hyperplasia. Moreover, only a moderate tendency to raise calcium and phosphate was observed. Doxercalciferol is orally-active and less toxic than other vitamin D analogs like alfacalcidol; it shows differentially controlled effects and has an improved safety profile compared to calcitriol.Doxercalciferol is a synthetic vitamin D2 analog introduced in the US as Hectorol for the treatment of secondary hyperparathyroidism (SHPT) in patients with end-stage renal failure. It is actually 1-alpha-hydroxyvitamin D2 (one-alpha- D2) and can be synthesized by direct hydroxylation of vitamin D2 tosylate or in 5 steps from ergosterol. Doxercalciferol itself is inactive until metabolized by the liver into active 1,24-dihydroxyvitamin D2, showing a pharmacokinetic profile similar to calcitriol. During placebo-controlled clinical trials, patients with moderate to severe SHPT were treated with 1-alpha-D2 (10 μg doses) for 16 to 24 weeks; in 9 patients out of 10, blood levels of parathyroid hormone were considerably reduced, so maintaining a good control of the parathyroid hyperplasia. Moreover, only a moderate tendency to raise calcium and phosphate was observed. Doxercalciferol is orally-active and less toxic than other vitamin D analogs like alfacalcidol; it shows differentially controlled effects and has an improved safety profile compared to calcitriol.<p><span style="font-family:arial,helvetica,sans-serif; font-size:14px">Doxercalciferol is&nbsp;</span>Crystalline Solid</p>

• Doxercalciferol CAS NO.54573-75-0 CAS NO.54573-75-0
• 
• US $1.00 /G
• CAS:54573-75-0
• Min. Order: 100G
• Purity: 99.9%
• Supply Ability: 50000 tons
• 2024-05-29

• Doxercalciferol
• 
• US $15.00-10.00/KG
• CAS:54573-75-0
• Min. Order: 1KG
• Purity: 99%+ HPLC
• Supply Ability: Monthly supply of 1 ton
• 2021-07-13

• Company Name:Shanghaizehan biopharma technology co., Ltd.
• Tel:021-61350663 13052117465
• Products Intro:Product Name:Doxercalciferol
  CAS:54573-75-0
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• CB Index:55
• Related Information:Catalog(1005)

• Company Name:MIDECO
• Tel:023-68625073 15723208759
• Products Intro:Product Name:Doxercalciferol
  CAS:54573-75-0
  Purity:99.7% HPLC Package:1g;50g
• CB Index:58
• Related Information:Catalog(68)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:4-Methylene-5-{2-[7a-methyl-1-(1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ylidene]-ethylidene}-cyclohexane-1,3-diol (1-alpha-Hydroxyvitamin D2)
  CAS:54573-75-0
  Package:10MG;1MG More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:Chemvon Biotechnology Co., Ltd
• Tel:021-50790412
• Products Intro:Product Name:Doxercalciferol
  CAS:54573-75-0
  Purity:98% Package:1g, 10g, 100g, 200g, 1kg, 5kg More...
• CB Index:57
• Related Information:Catalog(371)

• Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
• Tel:821-50328103-801 18930552037
• Products Intro:Product Name:Doxercalciferol;(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7α-Methyl-1-[(1R,2E)-1,4,5-triMethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
  CAS:54573-75-0
  Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More...
• CB Index:69
• Related Information:Catalog(15839)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7α-methyl-1-[(1R,2E)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
  CAS:54573-75-0
  Purity:98% HPLC Package:10mg;50mg;100mg;500mg;1g Remarks:Biochemical Reagents; Pharmaceutical Intermediates More...
• CB Index:61
• Related Information:Catalog(6005)