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Butylated Hydroxytoluene

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USE
Butylated hydroxytoluene is readily absorbed from the gastrointestinal tract and is metabolized and excreted in the urine mainly as glucuronide conjugates of oxidation products. Although there have been some isolated reports of adverse skin reactions, butylated hydroxytoluene is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.<br/> The WHO has set a temporary estimated acceptable daily intake for butylated hydroxytoluene at up to 125 μg/kg body-weight.<br/> Ingestion of 4 g of butylated hydroxytoluene, although causing severe nausea and vomiting, has been reported to be nonfatal.<br/> LD<sub>50</sub> (guinea pig, oral): 10.7 g/kg<br/> LD<sub>50</sub> (mouse, IP): 0.14 g/kg<br/> LD<sub>50</sub> (mouse, IV): 0.18 g/kg<br/> LD<sub>50</sub> (mouse, oral): 0.65 g/kg<br/> LD<sub>50</sub> (rat, oral): 0.89 g/kg
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