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Losartan

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114798-26-4 Basic informationMore
USE
Losartan, 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5-yl-phenyl)benzyl]imidazole-5-methanol monopotassiumsalt (Cozarr), was the first nonpeptide imidazole to beintroduced as an orally active angiotensin II antagonist withhigh specificity for AT1. When administered to patients, itundergoes extensive first-pass metabolism, with the 5-methanol being oxidized to a carboxylic acid. This metabolismis mediated by CYP 2C9 and 3A4 isozymes. The 5-methanol metabolite is approximately 15 times more potentthan the parent hydroxyl compound. Because the parent hydroxylcompound has affinity for the AT1 receptor, strictlyspeaking, it is not a prodrug.
Lastest Price from Losartan manufacturers
  • Losartan
  • US $5.00 /kg
  • CAS:114798-26-4
  • Min. Order: 1kg
  • Purity: 99.92%
  • Supply Ability: 50000tons
  • 2024-04-24
  • Losartan
  • US $220.00-85.00/Kg/Bag
  • CAS:114798-26-4
  • Min. Order: 1Kg/Bag
  • Purity: 99% up, High Density
  • Supply Ability: 20 tons
  • 2024-04-22

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  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:010-82848833 400-666-7788
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  • Company Name:Chembest Research Laboratories Limited
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  • Company Name:Adamas Reagent, Ltd.
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  • Products Intro:Product Name:(1-((2’-(1H-Tetrazol-5-Yl)-[1,1’-Biphenyl]-4-Yl)Methyl)-2-Butyl-4-Chloro-1H-Imidazol-5-Yl)Methanol
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  • Company Name:Daicel Chiral Technologies (China)CO.,LTD
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    Purity:95% HPLC Package:10mg ;25mg;50mg;100mg Remarks:DCTI-A-278
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  • Company Name:Hangzhou Yuhao Chemical Technology Co., Ltd
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