Camtobell hydrochloride

• Product Name:Camtobell hydrochloride
• Synonyms: BELOTECAN HYDROCHLORIDE CKD-602: BELOTECAN HYDROCHLORIDE (S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione hydrochloride Camtobell hydrochloride (S)-4-Ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol Belotecan hydrochloride(CKD-602) Belotecan HCl Belotecan Hydrochlorid
• CAS:213819-48-8
• MF:C25H28ClN3O4
• MW:469.97
• EINECS:
• Mol File:213819-48-8.mol
• 

<p>Camtobell hydrochloride, a DNA topoisomerase I inhibitor, is an analog of camptothecin. It was launched in the Republic of Korea as an injectable formulation for the treatment of ovarian and small cell lung cancer. Although camptothecin exhibits potent antineoplastic activity in vitro, its clinical application is hampered by severe toxicity and poor water solubility. Several synthetic and semi-synthetic analogs of camptothecin with improved solubility and lower toxicity have been developed over the past two decades. Two drugs from this class, topotecan and irinotecan, have been launched in previous years and belotecan is the newest member to reach the market. Camtobell hydrochloride is prepared by a two-step semi-synthesis starting from camptothecin, first by converting to 7-methylcamptothecin via a free-radical methylation reaction using a combination of acetic acid, tert-butylhydroperoxide, ferrous sulfate and sulfuric acid, and subsequently, in the second step, a Mannich reaction with isopropylamine hydrochloride and dimethylsulfoxide. A total synthesis of belotecan in seventeen steps starting from ethyl acetopyruvate is also reported. Belotecan inhibits topoisomerase I with approximately equal potency as camptothecin and about 3-fold higher potency than topotecan, with respective IC₅₀ values of 0.119, 0.123 and 0.33 μg/mL. Its cytotoxic activity is comparable to that of camptothecin, with IC₅₀ values ranging from 2 ng/mL to 2 μg/mL against 26 different human cancer cell lines. In studies using human tumor xenografts in nude mice, 80-100 mg/ kg of belotecan dosed every four days for four doses produced 67 to 94% tumor regression rates against HT-29, WIDR and CX-1 colon, LX-1 lung, MX-1 breast and SKOV-3 ovarian carcinomas. Pharmacokinetic studies of camtobell hydrochloride in rats at intravenous doses of 2.6–8.9 mg/kg demonstrated that both C_max and AUC increased in a dose-dependent manner. Total clearances, volumes of distribution and mean residence times did not change significantly with increasing doses. The elimination half-life ranged between 9.2 to 11.2 hours. In a Phase I study of camtobell hydrochloride, the fraction of renal clearance was found to be 33.1 to 50.3%, and the protein-binding fraction was 53 to 87%. Approximately 9.5% of the administered dose was excreted via the hepatobiliary system. In clinical studies involving 20 patients with recurrent or refractory ovarian cancer, intravenous administration of 0.5 mg/m²/day of belotecan for 5 days every 3 weeks over a median of six dosing cycles resulted in an overall response rate of 45%. All patients had grade 3 or 4 neutropenia as the most significant adverse event.</p>

• Camtobell hydrochloride
• 
• US $0.00-0.00/KG
• CAS:213819-48-8
• Min. Order: 1KG
• Purity: 98%
• Supply Ability: 1Ton
• 2022-10-14

• Company Name:Shanghai Tekanbio Pharm-Tech Co., Ltd.
• Tel:021-50896099 18017206244
• Products Intro:Product Name:Belotecan hydrochloride
  CAS:213819-48-8
  Purity:>98% Package:1g;100g;1kg
• CB Index:58
• Related Information:Catalog(109)

• Company Name:Abydos Scientific
• Tel:025-84767922 18936879710
• Products Intro:Product Name:Belotecan Hydrochloride
  CAS:213819-48-8
  Purity:0.99 Package:500g;100g;10g;1g
• CB Index:58
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• Company Name:ShangHai ChuanQian Chemcial Technique Centre
• Tel: 15869524721
• Products Intro:Product Name:(S)-7-methylcamptothecin
  CAS:213819-48-8
  Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,10G
• CB Index:58
• Related Information:Catalog(3991)

• Company Name:Wuhan Jingkangen Biomedical Technology Co., Ltd
• Tel:13720134139 13720134139
• Products Intro:Product Name:Belotecan
  CAS:213819-48-8
  Purity:98% Package:1G：5G
• CB Index:58
• Related Information:Catalog(5797)

• Company Name:Zhejiang Huida Biotech Co., LTD
• Tel:0571-89903882 13626641628
• Products Intro:Product Name:Belotecan HCL
  CAS:213819-48-8
  Purity:99% HPLC Package:10mg；100mg；1g；10g；100g
• CB Index:58
• Related Information:Catalog(3656)

• Company Name:Chengdu Zen Sunda Bio-pharmaceutical Technology Co., Ltd.
• Tel: 19981275275
• Products Intro:Product Name:Belotecan Hydrochlorid
  CAS:213819-48-8
  Purity:99% Package:100g, 1kg, 5kg
• CB Index:58
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• Company Name:YJ Pharma
• Tel:13962794339 13962794339
• Products Intro:Product Name:Belotecan Hydrochloride
  CAS:213819-48-8
  Purity:98% Package:5g;10g;500g；1kg
• CB Index:58
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• Company Name:WuYan Pharmaceutical Technology (Shanghai) Co., Ltd.
• Tel:021-61001086 13671938079
• Products Intro:Product Name:Camtobell hydrochloride
  CAS:213819-48-8
  Purity:99% Package:100g;1kg
• CB Index:55
• Related Information:Catalog(104)