Retigabine

• Product Name:Retigabine
• Synonyms: Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate RetigabineDiscontinued See: R189051 2-AMINO-4-(4-FLUORBENZYLAMINO)-1-ETHOXYCARBONYLAMINOBENZENE D2312 N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic Acid Ethyl Ester D 23129 Retigabin Ezogabine impurity
• CAS:150812-12-7
• MF:C16H18FN3O2
• MW:303.33
• EINECS:629-886-2
• Mol File:150812-12-7.mol
• 

Retigabine was approved in March 2011 by the European Commission for the adjunctive treatment of partial-onset seizures in adults who have epilepsy; in June 2011, the U.S. FDA approved the same drug, known in the United States as ezogabine. Retigabine differs from all currently approved antiepileptic drugs in that it acts as a selective positive allosteric modulator (opener) of KCNQ2-5 potassium channels, which are key regulators of neuronal excitability. The discovery of retigabine was based on modification of an analgesic agent flupirtine that had serendipitously shown potent anticonvulsant activity in animal models of epilepsy. Changing a central 2,3,6-triaminopyridine to a 1,2,4-triaminobenzene decreased analgesic activity while enhancing antiepileptic activity. Retigabine (D-23129) was shown to be a broad spectrum anticonvulsant with oral activity in a variety of animal models. The mechanism of action of retigabine was discovered well after its in vivo activity was recognized. Retigabine can be prepared by reductive amination of 2-ethoxycarbonylamino-5-(4-fluorobenzylamino)- nitrobenzene with 4-fluorobenzaldehyde, followed by hydrogenation in the presence of Raney nickel.

• Retigabine
• 
• US $0.00 /g
• CAS:150812-12-7
• Min. Order: 1g
• Purity: 99%HPLC
• Supply Ability: 500G
• 2025-02-06

• RETIGABINE
• 
• US $0.00-0.00/KG
• CAS:150812-12-7
• Min. Order: 1KG
• Purity: 99%
• Supply Ability: 5000
• 2024-12-06

• Company Name:TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.
• Tel:022-60182192,1339732154 18722583064
• Products Intro:Product Name:RETIGABINE
  CAS:150812-12-7
  Purity:98.00% Package:500g,1kg,25kg More...
• CB Index:61
• Related Information:Catalog(112)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Retigabine See also: R189051 (HCl salt)
  CAS:150812-12-7
  Package:100Mg,10Mg More...
• CB Index:76
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• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:Retigabine
  CAS:150812-12-7
  Purity:99% Package:100mg;500mg;1g;5g;10g;50g;100g;500g Remarks:C14097 More...
• CB Index:61
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• Company Name:Wuhu Huaren Science and Technology Co., Ltd.
• Tel:0553-0553-0553-5842013-801-801 18155347026
• Products Intro:Product Name:RETIGABINE
  CAS:150812-12-7
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• Company Name:Adamas Reagent, Ltd.
• Tel:400-6009262 16621234537
• Products Intro:Product Name:Retigabine
  CAS:150812-12-7
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• Company Name:Shanghai Longsheng chemical Co.,Ltd.
• Tel:021-58099652-8005 13585536065
• Products Intro:CAS:150812-12-7
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