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Pyrazinamide

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USE
Pyrazinecarboxamide (PZA) occurs as a white crystalline powder that is sparingly soluble in water and slightly soluble in polar organic solvents. Its antitubercular properties were discovered as a result of an investigation of heterocyclic analogs of nicotinic acid, with which it is isosteric. Pyrazinamide has recently been elevated to first-line status in short-term tuberculosis treatment regimens because of its tuberculocidal activity and comparatively low short-term toxicity. Since pyrazinamide is not active against metabolically inactive tubercle bacilli, it is not considered suitable for long-term therapy. Potential hepatotoxicity also obviates long-term use of the drug. Pyrazinamide is maximally effective in the low pH environment that exists in macrophages (monocytes). Evidence suggests bioactivation of pyrazinamide to pyrazinoic acid by an amidase present in mycobacteria.
Lastest Price from Pyrazinamide manufacturers
  • Pyrazinamide
  • US $1.00 /KG
  • CAS:98-96-4
  • Min. Order: 1KG
  • Purity: 99%~101.0% ,BP2015
  • Supply Ability: 5ton/month
  • 2026-01-12
  • Pyrazinamide
  • US $0.00 /kg
  • CAS:98-96-4
  • Min. Order: 1kg
  • Purity: 0.99
  • Supply Ability: 1000kg
  • 2025-04-25

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  • Company Name:Wuhan Fortuna Chemical Co., Ltd
  • Tel:+86-27-59207850
  • Products Intro:Product Name:Pyrazinamide
    CAS:98-96-4
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  • Company Name:ANHUI WITOP BIOTECH CO., LTD
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  • Company Name:Baoji Guokang Healthchem Co., Ltd.
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    Purity:0.98 Package:25KG;10KG;5KG;1KG
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  • Company Name:Dayang Chem (Hangzhou) Co.,Ltd.
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  • Products Intro:Product Name:Pyrazinamide
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    Purity:0.95&0.99 Package:0.1KG;1KG;1000KG Remarks:Factory Supply
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  • Products Intro:Product Name:1,2-dihydro-1,2,4-triazol-3-one
    CAS:98-96-4
    Purity:0.97 Package:mgs,gs,kgs Remarks:A845937
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