Roflumilast

• Product Name:Roflumilast
• Synonyms: ROFLUMILAST 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide B 9302-107 BY 217 BYK 20869 Daxas Roflumilast / 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
• CAS:162401-32-3
• MF:C17H14Cl2F2N2O3
• MW:403.21
• EINECS:685-382-2
• Mol File:162401-32-3.mol
• 

Roflumilast is taken orally and is metabolized by cytochrome oxidase P45(CYP)3A4 and CYP1A2 enzyme into N-oxide. Roflumilast N-oxide’s activity is only 2-3 times weaker than that of roflumilast, and it also has relatively high PDE-4 selectivity. 90% of PDE-4 inhibition in the body is achieved by roflumilast N-oxide, while the other 10% is achieved by the original drug. A daily 500ng oral dose of roflumilast for a healthy person will produce a free blood concentration of roflumilast N-oxide in 24 hours of about 1-2 nmol•L-1, and its serum protein binding rate is about 97%. Smoking has little impact on roflumilast’s pharmacokinetics. Roflumilast mostly affects inflammation cells related to asthma, including eosinophils, neutrophils, and mast cells. This drug can specifically affect a certain enzyme that participates in smooth muscle contraction, it can prevent cAMP decomposition, thus preventing the signal transduction for inflammatory reactions, and it is anti-inflammatory, giving it relatively good curative effects in clinically treating asthma and COPD. Roflumilast can also significantly extend the deterioration of respiratory symptoms while also dramatically increasing patients’ quality of life.

• Roflumilast
• 
• US $1.00 /kg
• CAS:162401-32-3
• Min. Order: 1kg
• Purity: 99
• Supply Ability: 100
• 2024-11-20

• Roflumilast
• 
• US $25.00 /ASSAYS
• CAS:162401-32-3
• Min. Order: 100ASSAYS
• Purity: 99.5%
• Supply Ability: 100 mt
• 2024-11-19

• Company Name:Anhui Beirui Pharmaceutical Technology Co., Ltd
• Tel:0551-68665055 18130089676
• Products Intro:Product Name:Roflumilast
  CAS:162401-32-3
  Purity:99% Package:5g;25g;100g;1kg;25kg
• CB Index:58
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• Company Name:Hefei TianRui Pharmaceutical Chemistry Co., Ltd.
• Tel:0551-68933033 13956024211
• Products Intro:Product Name:RofluMilast
  CAS:162401-32-3
  Purity:99% Package:1KG;10KG;1000KG More...
• CB Index:58
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• Company Name:Shanghai Famo Bio-chemical Technology Company Ltd.
• Tel:021-021-36680027 15800370750
• Products Intro:Product Name:Roflumilast
  CAS:162401-32-3
  Purity:99% Package:1KG;10KG Remarks:162401-32-3 More...
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• Company Name:SiChuang NanBu Honesty Technology Co., Ltd.
• Tel:0838-5675166 15883665058
• Products Intro:CAS:162401-32-3
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• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
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  CAS:162401-32-3
  Package:50Mg,5Mg More...
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• Company Name:ZHIWE CHEMTECH CO LTD
• Tel:021-20221225 13917446399
• Products Intro:Product Name:Roflumilast
  CAS:162401-32-3
  Purity:98% More...
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• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:RofluMilast
  CAS:162401-32-3
  Remarks:C14118 More...
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