Imipramine hydrochloride
113-52-0 Basic informationMore
- Product Name:Imipramine hydrochloride
- Synonyms: Imipramine hydrochloride,10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride Imipramine Hydrochloride (200 mg) Methanol(test Imipramine HCl, 1.0 mg/mL as free base) 10,11-Dihydro-N,N-dimithyl-5,H-dibenz[b,f]azepine-5-propanamine 5-(3-dimethylaminopropyl)-10,11-dihydro-5h-dibenz(b,f)azepinehydrochloride tofranil tofranile LABOTEST-BB LT00452014
- CAS:113-52-0
- MF:C19H25ClN2
- MW:316.87
- EINECS:204-030-7
- Mol File:113-52-0.mol
-
USE
Imipramine hydrochloride, 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine monohydrochloride(Tofranil), is the lead compound of the TCAs. It is also a closerelative of the antipsychotic phenothiazines (replace the10–11 bridge with sulfur, and the compound is the antipsychoticagent promazine). It has weaker D<sub>2</sub> postsynaptic blockingactivity than promazine and mainly affects amines (5-HT,NE, and DA) via the transporters. As is typical of dimethylaminocompounds, anticholinergic and sedative (central H<sub>1</sub>block) effects tend to be marked. The compound per se has a tendency toward a high 5-HT-to-NE uptake block ratio andprobably can be called a serotonin transport inhibitor(SERTI). Metabolic inactivation proceeds mainly by oxidativehydroxylation in the 2-position, followed by conjugationwith glucuronic acid of the conjugate. Urinary excretion predominates(about 75%), but some biliary excretion (up to25%) can occur, probably because of the large nonpolargrouping. Oxidative hydroxylation is not as rapid or completeas that of the more nucleophilic ring phenothiazine antipsychotics;consequently, appreciable N-demethylation occurs,with a buildup of norimipramine (or desimipramine).
Lastest Price from Imipramine hydrochloride manufacturers
- Imipramine hydrochloride
-
- US $67.00 /kg
- CAS:113-52-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000 tons
- 2024-02-27
- Imipramine hydrochloride
-
- US $1.00 /KG
- CAS:113-52-0
- Min. Order: 1G
- Purity: 98%
- Supply Ability: 100KG
- 2019-07-06
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:IMipraMine Hydrochloride
CAS:113-52-0
Package:10g,1g More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
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- Products Intro:Product Name:IMipraMine hydrochloride
CAS:113-52-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Company Name:TCI (Shanghai) Development Co., Ltd.
- Tel:021-67121386
- Products Intro:Product Name:Imipramine Hydrochloride
CAS:113-52-0
Purity:98.0% LC Package:1G,,25G,5G More... - CB Index:81
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- Company Name:Adamas Reagent, Ltd.
- Tel:400-6009262 16621234537
- Products Intro:Product Name:Imipramine Hydrochloride
CAS:113-52-0
Purity:98%+ Package:250mg;1g;5g;25g;100g - CB Index:59
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- Company Name:Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
- Tel:025-66099280 17798518460
- Products Intro:Product Name:Imipramine Hydrochloride
CAS:113-52-0
Purity:95% Package:1g;5g;10g More... - CB Index:55
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- Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD
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- Products Intro:Product Name:Imipramine Hydrochloride
CAS:113-52-0
Purity:>98.0%(HPLC) Package:711RMB/5G More... - CB Index:65
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