Imipramine hydrochloride
113-52-0 Basic informationMore
- Product Name:Imipramine hydrochloride
- Synonyms: Imipramine hydrochloride,10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride Imipramine Hydrochloride (200 mg) Methanol(test Imipramine HCl, 1.0 mg/mL as free base) 10,11-Dihydro-N,N-dimithyl-5,H-dibenz[b,f]azepine-5-propanamine 5-(3-dimethylaminopropyl)-10,11-dihydro-5h-dibenz(b,f)azepinehydrochloride tofranil tofranile LABOTEST-BB LT00452014
- CAS:113-52-0
- MF:C19H25ClN2
- MW:316.87
- EINECS:204-030-7
- Mol File:113-52-0.mol
USE
Imipramine hydrochloride, 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine monohydrochloride(Tofranil), is the lead compound of the TCAs. It is also a closerelative of the antipsychotic phenothiazines (replace the10–11 bridge with sulfur, and the compound is the antipsychoticagent promazine). It has weaker D<sub>2</sub> postsynaptic blockingactivity than promazine and mainly affects amines (5-HT,NE, and DA) via the transporters. As is typical of dimethylaminocompounds, anticholinergic and sedative (central H<sub>1</sub>block) effects tend to be marked. The compound per se has a tendency toward a high 5-HT-to-NE uptake block ratio andprobably can be called a serotonin transport inhibitor(SERTI). Metabolic inactivation proceeds mainly by oxidativehydroxylation in the 2-position, followed by conjugationwith glucuronic acid of the conjugate. Urinary excretion predominates(about 75%), but some biliary excretion (up to25%) can occur, probably because of the large nonpolargrouping. Oxidative hydroxylation is not as rapid or completeas that of the more nucleophilic ring phenothiazine antipsychotics;consequently, appreciable N-demethylation occurs,with a buildup of norimipramine (or desimipramine).
Lastest Price from Imipramine hydrochloride manufacturers
- Imipramine HCl
- US $0.00 /kg
- CAS:113-52-0
- Min. Order: 20kg
- Purity: 99%
- Supply Ability: 20 tons
- 2024-11-12
- Imipramine hydrochloride
- US $1.00 /KG
- CAS:113-52-0
- Min. Order: 1G
- Purity: 98%
- Supply Ability: 100KG
- 2019-07-06
Browse by Nationality 113-52-0 Suppliers >Global suppliers
Beijing (12) Shanghai (46) Tianjin (2) Chongqing (2) Sichuan (1) Guizhou (1) Guangdong (15) Zhejiang (10) Fujian (1) Hubei (12) Shandong (2) Henan (7) Anhui (5) Jiangsu (13) Jiangxi (1) Shaanxi (2) Hong Kong (2) Other (8) Member (118) All (142)
Please select the suppliers
Recommend You Select Member Companies
Recommend You Select Member Companies
- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:IMipraMine Hydrochloride
CAS:113-52-0
Package:10g,1g More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:IMipraMine hydrochloride
CAS:113-52-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15839)
- Company Name:TCI (Shanghai) Development Co., Ltd.
- Tel:021-67121386
- Products Intro:Product Name:Imipramine Hydrochloride
CAS:113-52-0
Purity:98.0% LC Package:1G,,25G,5G More... - CB Index:81
- Related Information:Catalog(24529)
- Company Name:Adamas Reagent, Ltd.
- Tel:400-6009262 16621234537
- Products Intro:Product Name:Imipramine Hydrochloride
CAS:113-52-0
Purity:98%+ Package:250mg;1g;5g;25g;100g - CB Index:59
- Related Information:Catalog(14103)
- Company Name:S.Z. PhyStandard Bio-Tech. Co., Ltd.
- Tel:0755-4000505016 13380397412
- Products Intro:Product Name:Imipramine HCl
CAS:113-52-0
Purity:98%HPLC Package:10mg;25mg;50mg;100mg - CB Index:50
- Related Information:Catalog(5047)
- Company Name:Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
- Tel:025-66099280 17798518460
- Products Intro:Product Name:Imipramine Hydrochloride
CAS:113-52-0
Purity:95% Package:1g;5g;10g More... - CB Index:55
- Related Information:Catalog(19915)