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Imipramine hydrochloride

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113-52-0 Basic informationMore
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Imipramine hydrochloride, 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine monohydrochloride(Tofranil), is the lead compound of the TCAs. It is also a closerelative of the antipsychotic phenothiazines (replace the10–11 bridge with sulfur, and the compound is the antipsychoticagent promazine). It has weaker D<sub>2</sub> postsynaptic blockingactivity than promazine and mainly affects amines (5-HT,NE, and DA) via the transporters. As is typical of dimethylaminocompounds, anticholinergic and sedative (central H<sub>1</sub>block) effects tend to be marked. The compound per se has a tendency toward a high 5-HT-to-NE uptake block ratio andprobably can be called a serotonin transport inhibitor(SERTI). Metabolic inactivation proceeds mainly by oxidativehydroxylation in the 2-position, followed by conjugationwith glucuronic acid of the conjugate. Urinary excretion predominates(about 75%), but some biliary excretion (up to25%) can occur, probably because of the large nonpolargrouping. Oxidative hydroxylation is not as rapid or completeas that of the more nucleophilic ring phenothiazine antipsychotics;consequently, appreciable N-demethylation occurs,with a buildup of norimipramine (or desimipramine).
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  • Imipramine HCl
  • US $0.00 /kg
  • CAS:113-52-0
  • Min. Order: 20kg
  • Purity: 99%
  • Supply Ability: 20 tons
  • 2024-11-12

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  • Company Name:J & K SCIENTIFIC LTD.
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  • Products Intro:Product Name:IMipraMine Hydrochloride
    CAS:113-52-0
    Package:10g,1g More...
  • CB Index:76
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  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
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  • Products Intro:Product Name:IMipraMine hydrochloride
    CAS:113-52-0
    Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More...
  • CB Index:69
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  • Company Name:TCI (Shanghai) Development Co., Ltd.
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  • Products Intro:Product Name:Imipramine Hydrochloride
    CAS:113-52-0
    Purity:98.0% LC Package:1G,,25G,5G More...
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  • Products Intro:Product Name:Imipramine Hydrochloride
    CAS:113-52-0
    Purity:98%+ Package:250mg;1g;5g;25g;100g
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  • Company Name:S.Z. PhyStandard Bio-Tech. Co., Ltd.
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  • Products Intro:Product Name:Imipramine HCl
    CAS:113-52-0
    Purity:98%HPLC Package:10mg;25mg;50mg;100mg
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  • Company Name:Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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  • Products Intro:Product Name:Imipramine Hydrochloride
    CAS:113-52-0
    Purity:95% Package:1g;5g;10g More...
  • CB Index:55
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