Rofecoxib
162011-90-7 Basic informationMore
- Product Name:Rofecoxib
- Synonyms: 4-[4-(MethylSLdfonyl)phenyl]-3-phenyl-2(5H)-furanone 4-[4-(Methylsulfonyl)phenyl]-3-phenyl- Rofecoxib(Vioxx) Rofecoxib (MK0966) Rofecoxid ROFECOXIB MK-0966 VIOXX
- CAS:162011-90-7
- MF:C17H14O4S
- MW:314.36
- EINECS:803-260-0
- Mol File:162011-90-7.mol
USE
Rofecoxib ts a non-steroidal anti-inflammatory drug (NSAID) launched
in Mexico, its first market, for the management of acute pain and the treatment
of osteoarthritis (OA) and primary dysmenorrhea. Rofecoxib can be obtained by
several different ways; one example is by arylation of a 4-bromofuranone with a
phenylboronic acid under Suzuki conditions. Rofecoxib is a highly selective
inhibitor of COX-2, the inducible isoform of cyclooxygenase and therefore
exhibits a potent antiinflammatory activity without concomitant gastric or renal
toxicities linked to the non-specific COX-1/2 inhibitors. In several clinical studies
in patients with knee or hip osteoarthritis, Rofecoxib was evaluated at 12.5-50
mg doses once daily: it demonstrated efficacy for all primary and secondary endpoints at doses considerably weaker than those for classical non-specific
NSAIDs, with good tolerance and less adverse effects. Selective COX-2
inhibitors potentially have a large spectrum of activity including new indications
such as Alzheimer's disease, colorectal cancer, irritable bowel disease or
urinary incontinence.
Lastest Price from Rofecoxib manufacturers
- Rofecoxib
- US $0.00 /G
- CAS:162011-90-7
- Min. Order: 1G
- Purity: 98%min
- Supply Ability: 300KG/month
- 2024-11-22
- Rofecoxib
- US $10.00-7.00/kg
- CAS:162011-90-7
- Min. Order: 1kg
- Purity: 99.9%
- Supply Ability: 20ton
- 2024-08-20
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- Company Name:Aribo Pharmatech Co., Ltd.
- Tel: 19951442182
- Products Intro:Product Name:Rofecoxib
CAS:162011-90-7
Purity:98%+ Package:g;kg - CB Index:58
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Vioxx
CAS:162011-90-7
Package:100Mg,1g More... - CB Index:76
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:Rofecoxib
CAS:162011-90-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15839)
- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:Rofecoxib(Vioxx)
CAS:162011-90-7
Remarks:C14117 More... - CB Index:61
- Related Information:Catalog(6005)
- Company Name:Beijing Ouhe Technology Co., Ltd
- Tel:010-82967028 13552068683
- Products Intro:Product Name:Rofecoxib
CAS:162011-90-7
Purity:98% Package:10g;50g;100g;250g;500g More... - CB Index:60
- Related Information:Catalog(12390)
- Company Name:Adamas Reagent, Ltd.
- Tel:400-6009262 16621234537
- Products Intro:Product Name:Rofecoxib
CAS:162011-90-7
Purity:99% Package:100mg;250mg;1g;5g;25g - CB Index:59
- Related Information:Catalog(14103)