5-Fluoroorotic acid

• Product Name:5-Fluoroorotic acid
• Synonyms: 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicaci 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicacid nsc31712 ro2-9945 2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid 5-FLUOROURACIL-4-CARBOXYLIC ACID 5' FOA 5-FLUORO-2,6-DIOXO-3H-PYRIMIDINE-4-CARBOXYLIC ACID
• CAS:703-95-7
• MF:C5H3FN2O4
• MW:174.09
• EINECS:211-876-0
• Mol File:703-95-7.mol
• 

<p>5-FOA(5-Fluoroorotic acid ) has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.</p>

• 5-Fluoroorotic acid
• 
• US $1.00 /kg
• CAS:703-95-7
• Min. Order: 1kg
• Purity: 99%
• Supply Ability: 10 mt
• 2024-11-18

• 5-Fluoroorotic Acid
• 
• US $10.00 /KG
• CAS:703-95-7
• Min. Order: 1KG
• Purity: 98%
• Supply Ability: 10 ton
• 2024-10-11

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:5-Fluoroorotic acid hydrate, 98%
  CAS:703-95-7
  Purity:98% Package:100MG;1G;5G More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
• Tel:021-61259108 18621169109
• Products Intro:Product Name:5-Fluoroorotic Acid Monohydrate
  CAS:703-95-7
  Purity:>95.0%(T) Package:100Mg;1g Remarks:F0382 More...
• CB Index:62
• Related Information:Catalog(40228)

• Company Name:TCI (Shanghai) Development Co., Ltd.
• Tel:021-67121386
• Products Intro:Product Name:5-Fluoroorotic Acid Monohydrate
  CAS:703-95-7
  Purity:95.0 Package:450RMB/100MG More...
• CB Index:81
• Related Information:Catalog(24529)

• Company Name:Energy Chemical
• Tel:021-021-58432009 400-005-6266
• Products Intro:Product Name:5-Fluoroorotic acid
  CAS:703-95-7
  Purity:95% Package:100MG,1G More...
• CB Index:61
• Related Information:Catalog(44689)

• Company Name:Beijing Ouhe Technology Co., Ltd
• Tel:010-82967028 13552068683
• Products Intro:Product Name:5-Fluoroorotic acid
  CAS:703-95-7
  Purity:98% Package:10g;50g;100g;250g;500g More...
• CB Index:60
• Related Information:Catalog(12390)