Alectinib
1256580-46-7 Basic informationMore
- Product Name:Alectinib
- Synonyms: AF-802 CH-5424802/RG-7853 Alectinib AF-802,RG-7853 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib (CH5424802) CH5424802-alectinib 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile CH5424802 CH5424802, Alectinib, AF802
- CAS:1256580-46-7
- MF:C30H34N4O2
- MW:482.62
- EINECS:821-541-6
- Mol File:1256580-46-7.mol
-
USE
Alectinib (Alecensa(R), Roche) was approved first in Japan in 2014 and then by US FDA in 2015 as a second-generation ALK inhibitor for NSCLC treatment on patients who have progressed or do not tolerate crizotinib. Developed through a structure-based drug design approach, alectinib is a benzocarbazolone derivative that has shown potent inhibitory activity against ALK (IC50 value of 1.9 nM) and gatekeeper mutant L1196M ALK (IC50 value of 1.6 nM). Alectinib is effective with crizotinib-resistant ALK mutations on L1196M, F1174L, R1275Q, and C1156Y. In addition, an array of small-molecule inhibitors are currently being evaluated by several clinical trials for ALK-driven tumors.
Lastest Price from Alectinib manufacturers
- Alectinib
-
- US $0.00 /g
- CAS:1256580-46-7
- Min. Order: 1g
- Purity: More Than 99%
- Supply Ability: 100kg/Month
- 2024-12-23
- Alectinib
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- US $0.00 /Kg/Bag
- CAS:1256580-46-7
- Min. Order: 1KG
- Purity: 99%min
- Supply Ability: 500kgs
- 2024-12-13
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- Company Name:Chengdu aibike Pharmaceutical Technology Co., Ltd
- Tel: 13708075524
- Products Intro:Product Name:Alectinib
CAS:1256580-46-7
Purity:0.99 Package:5kg Remarks:10kg - CB Index:58
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- Company Name:Shanghai Famo Bio-chemical Technology Company Ltd.
- Tel:021-021-36680027 15800370750
- Products Intro:Product Name:Alectinib
CAS:1256580-46-7
Purity:98% More... - CB Index:56
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- Company Name:Hubei Hicks Biochemical Co., Ltd
- Tel:17362916295; 17362916295
- Products Intro:CAS:1256580-46-7
Purity:99% HPLC Package:5KG;1KG Remarks:KG - CB Index:58
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- Company Name:NANJING ZENJI PHARMACEUTICALS
- Tel:025-58231105-8151 15190133791;
- Products Intro:Product Name:Alectinib
CAS:1256580-46-7
Purity:99% Package:1g;10g;100g;1kg - CB Index:58
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- Company Name:Nanjing Becas pharmatech Ltd.
- Tel: 13912903754
- Products Intro:Product Name:Alectinib
CAS:1256580-46-7
Purity:97% HPLC Package:1g,5g,10g,25g - CB Index:58
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:CH5424802
CAS:1256580-46-7
Package:100Mg,10Mg,50Mg,5Mg More... - CB Index:76
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