Linsitinib

• Product Name:Linsitinib
• Synonyms: cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol Linsitinib OSI-906 Linsitinib Cyclobutanol, 3-[8-aMino-1-(2-phenyl-7-quinolinyl)iMidazo[1,5-a]pyrazin-3-yl]-1-Methyl-, cis- OSI 906AA (1S,3r)-3-((S)-8-aMino-1-(2-phenylquinolin-7-yl)-2,3-dihydroiMidazo[1,5-a]pyrazin-3-yl)-1-Methylcyclobutanol (1s,3r)-3-[4-aMino-3-(2-phenylquinolin-7-yl)iMidazo[1,5-a]pyrazin-1-yl]-1-Methylcyclobutan-1-ol Linsitinib, Free Base
• CAS:867160-71-2
• MF:C26H23N5O
• MW:421.49
• EINECS:1533716-785-6
• Mol File:867160-71-2.mol
• 

OSI-906 inhibits tumor growth in an IGF-1R-driven xenograft mouse model, with 100% TGI and 55% regression at a dose of 75 mg/kg and 60% TGI and no regression at a dose of 25 mg/kg. OSI-906 administration induces different elimination half-lives of itself in dog, rat and mice, the elimination half-lives are 1.18 hours, 2.64 hours and 2.14 hours, respectively. OSI-906 administration at different single dose once-daily in femal Sprague-Dawley rat and femal CD-1 mouse reveal that the Vmax is not dose-proportional to OSI-906 dose. OSI-906 elevates the blood glucose levels at a dose of 25 mg/kg after 12 days administration. OSI-906 administration at a single dose of 75 mg/kg in IGF-1R-driven full-length human IGF-1R (LISN) xenograft mouse model achieve maximal inhibition of IGF-1R phosphorylation (80%) between 4 and 24 hours with plasma drug concentrations of 26.6-4.77 μM. OSI-906 administered as a single dose of at 60 mg/kg in NCI-H292 xenografts mice inhibits uptake of glucose at 2, 4, and 24 hours post-treatment in vivo. OSI-906 inhibits the growth of tumors in NCI-H292 xenograft mouse model.

• Linsitinib
• 
• US $0.00-0.00/KG
• CAS:867160-71-2
• Min. Order: 1KG
• Purity: 98%
• Supply Ability: 1Ton
• 2022-10-14

• Company Name:Shanghai XingMo Biotechnology Co., Ltd.
• Tel: 13524779951
• Products Intro:Product Name:OSI-906 (Linsitinib)
  CAS:867160-71-2
  Purity:99% Package:1g,5g,10g More...
• CB Index:55
• Related Information:Catalog(309)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Linsitinib
  CAS:867160-71-2
  Package:100Mg,50Mg,5Mg More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:Chembest Research Laboratories Limited
• Tel:021-20908456
• Products Intro:Product Name:Linsitinib (OSI-906)
  CAS:867160-71-2
  Purity:98+% Package:1g;5g;10g Remarks:C13962 More...
• CB Index:61
• Related Information:Catalog(6011)

• Company Name:Jia Xing Isenchem Co.,Ltd
• Tel:0573-85285100 18627885956
• Products Intro:CAS:867160-71-2
  Purity:98% (HPLC or GC) Package:25g,100g,500g;1kg More...
• CB Index:66
• Related Information:Catalog(9551)