Entacapone
130929-57-6 Basic informationMore
- Product Name:Entacapone
- Synonyms: (E)-2-Cyano-3-(3，4-dihydroxy-5-nitrophenyl)-N，N-diethyl-2-pmpenamide Entacapone (150 mg) (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enaMide 2-PropenaMide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)- Entacapone (isomer E) (E)-2-cyano-3-(5-(dihydroxyamino)-3,4-dioxocyclohexa-1,5-dienyl)-N,N-diethylacrylamide ENTACAPONE 2-cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-n,n-diethyl-prop-2-enamide
- CAS:130929-57-6
- MF:C14H15N3O5
- MW:305.29
- EINECS:212-686-0
- Mol File:130929-57-6.mol
-
USE
Entacapone was introduced in Finland, Germany and Sweden as an
adjunctive treatment with L-dopa in Parkinson’s disease. Entacapone is the
second drug in its class to reach the market; it can be obtained by
basecatalyzed condensation of the corresponding benzaldehyde with a
cyanoacetamide. Entacapone is a highly selective and orally-active catechol-0-
methyltransferase (COMT) inhibitor ; by inhibiting metabolism of L-dopa when
given as an adjuvant in patients with Parkinson’s disease, Entacapone markedly
prolongs the effects of L-dopa and improves its bioavailability. Results from
clinical studies showed that 200mglday Entacapone coadministered with L-dopa
lowered the dose of the latter required to reduce fluctuations in motor
performance.
Lastest Price from Entacapone manufacturers
- Entacapone
-
- US $40.00-40.00/kg
- CAS:130929-57-6
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 10 tons
- 2023-12-11
- Entacapone
-
- US $50.00 /kg
- CAS:130929-57-6
- Min. Order: 1kg
- Purity: 99.9%
- Supply Ability: 10000MT
- 2023-09-07
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- Company Name:Hunan Kaimir Biotechnology Co., Ltd.
- Tel:+86-0731-89714511 +86-18602659358
- Products Intro:Product Name:Entacapone
CAS:130929-57-6
Purity:99% Package:20kg More... - CB Index:58
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- Company Name:Zhejiang Jianfeng Haizhou Pharmaceutical Co., Ltd.
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