Tafamidis Meglumine

• Product Name:Tafamidis Meglumine
• Synonyms: Tafamidis Meglumine 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole meglumine cas 594839-88-0 PF06291826 PF-06291826 TAFAMIDIS;CAS 594839-88-0;PF-06291826;PF06291826 Tafamidis meglumine (Fx1006, PF06291826) tafamidis meglumine,Inhibitor,Tafamidis,inhibit
• CAS:951395-08-7
• MF:C21H24Cl2N2O8
• MW:503.33
• EINECS:
• Mol File:951395-08-7.mol
• 

In November 2011, the European Commission approved tafamidis meglumine (Fx-1006A, PF-06291826) for the treatment of transthyretin familial amyloid polyneuropathy (TTR-FAP) in adult patients with stage 1 symptomatic polyneuropathy. Tafamidis stabilizes both the wild type and mutant forms of TTR tetramer and prevents tetramer dissociation by noncooperatively binding to the two thyroxine binding sites. Tafamidis is the first approved medicine for TTR-FAP. The Kd values for tafamidis for the two thyroxine binding sites on TTR, as determined by isothermal titration calorimetry, were 3 nM and 278 nM, respectively. In another in vitro study using wild type TTR, V30M mutant TTR, and V122I mutant TTR, it was shown that tafamidis inhibited fibril formation in a concentration-dependent manner reaching EC₅₀ at a tafamidis:TTR stoichiometry of <1 (EC₅₀ was in the range of 2.7–3.2 μM, corresponding to a tafamidis:TTR stoichiometry range of 0.75–0.9). Tafamidis has been synthesized by coupling 4-amino-3- hydroxybenzoic acid with 3,5-dichlorobenzoyl chloride followed by dehydration using p-toluenesulfonic acid.

• Tafamidis Meglumine
• 
• US $0.00-0.00/KG
• CAS:951395-08-7
• Min. Order: 1KG
• Purity: 99%
• Supply Ability: 500000kg
• 2024-11-04

• Company Name:SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.
• Tel:021-34666753 13311639313
• Products Intro:Product Name:Tafamidis Meglumine
  CAS:951395-08-7
  Purity:98%/99% Package:根据客户要求 Remarks:API
• CB Index:55
• Related Information:Catalog(571)

• Company Name:Shanghai Lollane Biological Technology Co.,Ltd.
• Tel:021-52996696，15000506266 15000506266
• Products Intro:Product Name:Tafamidis meglumine
  CAS:951395-08-7
  Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g
• CB Index:55
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• Company Name:Cangzhou Enke Pharma-tech Co., Ltd.
• Tel:0317-5296180 15533709196
• Products Intro:Product Name:Tafamidis Meglumine
  CAS:951395-08-7
  Purity:99%化工级 沧州恩科医药科技，大量现货，优势产品，欢迎询价下单，随时为您服务！ Package:1公斤/RMB 999;2公斤/RMB 999;10公斤/RMB 999
• CB Index:55
• Related Information:Catalog(1937)

• Company Name:ShangHai Biochempartner Co.,Ltd
• Tel:17754423994 17754423994
• Products Intro:Product Name:Tafamidis meglumine
  CAS:951395-08-7
  Purity:98% HPLC LCMS Package:100mg;500mg;1g;5g;10g
• CB Index:62
• Related Information:Catalog(8011)

• Company Name:Amadis Chemical Company Limited
• Tel:571-89925085
• Products Intro:Product Name:Tafamidis meglumine
  CAS:951395-08-7
  Purity:0.97 Package:mgs,gs,kgs Remarks:A931101
• CB Index:58
• Related Information:Catalog(131957)

• Company Name:Hubei widely chemical technology Co., Ltd.
• Tel:027-59402396 13419635609
• Products Intro:Product Name:Tafamidis meglumine
  CAS:951395-08-7
  Purity:98%
• CB Index:55
• Related Information:Catalog(1985)

• Company Name:Wuhan Wsem Biological Co., Ltd.
• Tel:027-83778876 13667159345
• Products Intro:Product Name:Tafamidis meglumine
  CAS:951395-08-7
  
• CB Index:55
• Related Information:Catalog(1999)

• Company Name:Wellman Pharmaceutical Group Limited
• Tel:027-83778875 15807197853
• Products Intro:Product Name:Tafamidis meglumine
  CAS:951395-08-7
  Purity:98% Package:10g;100g;350g
• CB Index:58
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