GSK 189254A
720690-73-3 Basic informationMore
- Product Name:GSK 189254A
- Synonyms: GSK 189254A 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-MethylnicotinaMide N-(4-METHOXYBENZYL)-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B<WBR />]PYRIDIN-4-AMINE 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methylpyridine-3-carboxamide histamine H3 receptor antagonist GS189254A CS-2905 3-Pyridinecarboxamide, 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl- Histamine Receptor,GSK-189254,GSK 189254,GSK-189254A,inhibit,GSK189254A,Inhibitor
- CAS:720690-73-3
- MF:C21H25N3O2
- MW:351.44
- EINECS:
- Mol File:720690-73-3.mol
-
USE
GSK189254A is a histamine H3 receptor antagonist for the treatment of narcolepsy.It may also be useful for the treatment of dementia and neuropathic pain. Its pharmacological effect may be related to its effect on increasing the release neurotransmitter in the brain. Microdialysis studies demonstrated that GSK189254 increased the release of acetylcholine, noradrenaline, and dopamine in the anterior cingulate cortex and acetylcholine in the dorsal hippocampus. GSK189254 significantly improved performance of rats in diverse cognition paradigms, including passive avoidance, water maze, object recognition, and attentional set shift. These data suggest that GSK189254 may have therapeutic potential for the symptomatic treatment of dementia in Alzheimer's disease and other cognitive disorders.
Browse by Nationality 720690-73-3 Suppliers >Global suppliers
Beijing (1) Shanghai (19) Tianjin (1) Sichuan (4) Guangdong (2) Zhejiang (1) Hubei (2) Shandong (1) Henan (1) Anhui (1) Jiangsu (6) Hong Kong (1) Other (1) Member (41) All (41)
Please select the suppliers
Recommend You Select Member Companies
Recommend You Select Member Companies
- Company Name:Shanghai Lollane Biological Technology Co.,Ltd.
- Tel:021-52996696，15000506266 15000506266
- Products Intro:Product Name:GSK189254A
CAS:720690-73-3
Purity:98% HPLC Package:5mg,10mg,50mg,100mg,1g,5g More... - CB Index:55
- Related Information:Catalog(4512)
- Company Name:Shanghaizehan biopharma technology co., Ltd.
- Tel:021-61350663 13052117465
- Products Intro:Product Name:GSK189254A
CAS:720690-73-3
Purity:98% Package:1g/;5g/ - CB Index:55
- Related Information:Catalog(1009)
- Company Name:Shanghai Synchem Pharma Co., ltd
- Tel:21-619849051-1 18521059765
- Products Intro:Product Name:GSK 189254A
CAS:720690-73-3
Purity:95%+; 98%+ Package:1kg;25kg - CB Index:55
- Related Information:Catalog(6463)
- Company Name:Shanghai EFE Biological Technology Co., Ltd.
- Tel:021-65675885 18964387627
- Products Intro:Product Name:GSK189254A
CAS:720690-73-3
Purity:98.00% Package:1mg;5mg;10mg More... - CB Index:58
- Related Information:Catalog(9806)
- Company Name:ShangHai Biochempartner Co.,Ltd
- Tel:177-54423994 17754423994
- Products Intro:Product Name:GSK-189254A
CAS:720690-73-3
Purity:98% HPLC LCMS Package:100mg;500mg;1g;5g;10g - CB Index:62
- Related Information:Catalog(8011)
- Company Name:Shanghai Rechem science Co., Ltd.
- Tel:21-31433387 15618786686
- Products Intro:CAS:720690-73-3
Purity:98% Package:1g/ - CB Index:58
- Related Information:Catalog(2992)
- Company Name:Shanghai Chaolan Chemical Technology Center
- Tel:021-QQ：65489617 15618227136
- Products Intro:Product Name:GSK-189254A
CAS:720690-73-3
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G More... - CB Index:58
- Related Information:Catalog(7267)