Liranaftate
88678-31-3 Basic informationMore
- Product Name:Liranaftate
- Synonyms: LNF O-(5,6,7,8-tetrahydronaphthalen-2-yl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate carbamothioicacid,(6-methoxy-2-pyridinyl)methyl-,o-(5,6,7,8-tetrahydro-2-na phthalenyl)ester LIRANAFATE LIRANAFTATE M-732 (6-METHOXY-2-PYRIDINYL)-METHYLCARBAMOTHIOIC ACID O-(5,6,7,8-TETRAHYDRO-2-NAPHTHALENYL) ESTER
- CAS:88678-31-3
- MF:C18H20N2O2S
- MW:328.43
- EINECS:000-000-0
- Mol File:88678-31-3.mol
-
USE
Liranaftate was launched in Japan as a new topical antifungal for the treatment of
dermatophycoses. This compound belonging to the thiocarbamate class of antifungals can
be prepared by condensation of 5,6，7,8-tetrahydro-2-naphthol with the corresponding Npyridylthiocarbamoyl
chloride. It is a potent and specific inhibitor of squalene epoxidase
and consequently a blocker of ergosterol biosynthesis in fungi, without any detectable
effect on mammalian cholesterol biosynthesis in rat liver at therapeutic dose levels.
Liranaftate was found to be significantly more active than the other thiocarbamate
tolnaftate against several dermatophytes, including Trichophyton mentagrophyfes, and
against certain yeasts, such as Crypfococcus neoformans. On the other hand, it was
inactive against a variety of Gram-positive and negative bacteria. When applicated as a 1 or 2% cream during clinical trials, it was well tolerated and no systemic absorption was observed.
Lastest Price from Liranaftate manufacturers
- Liranaftate
-
- US $0.00 /KG
- CAS:88678-31-3
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 100KGS
- 2024-07-24
- Liranaftate
-
- US $0.00 /KG
- CAS:88678-31-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100 MT
- 2024-05-28
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- Company Name:Jinan Wald Chemical Co., Ltd.
- Tel:0531-88773586 13210588999
- Products Intro:Product Name:Liranaftate
CAS:88678-31-3
Purity:99.9 - CB Index:58
- Related Information:Catalog(193)
- Company Name:NanJing Jiexin chemicals Co.,Ltd
- Tel:15005178685; 15005178685
- Products Intro:Product Name:Liranaftate
CAS:88678-31-3
Purity:99% HPLC Package:25KG,5KG,1kg - CB Index:58
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Liranaftate
CAS:88678-31-3
Package:100Mg,10Mg More... - CB Index:76
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- Company Name:Jiangsu Huayu Chemical Co., Ltd.
- Tel:25-83241163
- Products Intro:Product Name:Liranaftate
Purity:98% Package:1kg/bag - CB Index:55
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:Liranaftate
CAS:88678-31-3
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Company Name:TCI (Shanghai) Development Co., Ltd.
- Tel:021-67121386
- Products Intro:Product Name:Liranaftate
CAS:88678-31-3
Purity:98.0% LC Package:250MG,50MG More... - CB Index:81
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- Company Name:XiaoGan ShenYuan ChemPharm co,ltd
- Tel: 15527768850
- Products Intro:CAS:88678-31-3
More... - CB Index:52
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