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133454-47-4

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133454-47-4 Basic informationMore
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Iloperidone, an atypical antipsychotic drug, is the dual antagonist of the serotonin-2 (5-HT2) and dopamine 2 (D2). The development process of iloperidone is a bit dramatic. It is originally synthesized and identified by HE Manchester-Russell pharmaceutical companies, however, the company decided to give up further development of it, and assigned it to the Titan Pharmaceuticals; At January 1997, Titan Pharmaceuticals further transferred the goods to Novartis, and the latter one invested the III phase of the clinical development of this product and assume the registration fees of this drugs worldwide except Japan (Titan Pharmaceuticals retains the right to develop this product in Japan); however, in 2004, the Vanda Pharmaceuticals in 2004 obtain the right to develop this product from Novartis. On May 6, 2009, the US FDA approved that Vanda Pharma Company had successfully developed iloperidone (trade name: Fanapt) and make it enter into market which is mainly used for clinical treatment of adults schizophrenia.<br/> As an orally administrated atypical antipsychotics drug, iloperidone has a obvious efficacy on reducing the positive symptoms (such as hallucinations, delusions, thought disorder, hostility, suspicion) of patients with schizophrenia as well as negative symptoms (such as unresponsiveness, emotional apathy, social apathy, of few words). Iloperidone belongs to the antagonist of 5-HT2/D2 receptor, and have a high affinity to dopamine D3 receptors. It also has appropriate affinity to the adrenergic A1 receptor, the dopamine D4 receptor, and 5-HT6 and 5-HT7 but also has a low affinity to 5-HT1A, dopamine D1 and H1 histamine receptor. Compared with currently used antipsychotics, short-term and long-term safety trials has showed that iloperidone has less adverse reactions without only minor increase of the quality of patient body. Iloperidone will not induce diabetic for the patients and also cause only a few of extrapyramidal system symptoms (such as no akathisia, no hyperprolactinemia, lower incidence of drowsiness, low decrease in cognitive decline). The clinical study has showed that iloperidone has a good safety and tolerability with good metabolism. It is mainly excreted out by the liver. The most common adverse reactions iloperidone include dizziness, dry mouth, fatigue, nasal congestion, orthostatic hypotension, lethargy, elevated heart rate, increased body mass, and prolonged QT phase. Iloperidone can also increase the risk of death in patients of Alzheimer's psychosis; thus patients of Alzheimer's psychosis are not allowed to use this drug.<br/> The above information is edited by the Chemicalbook of Dai Xiongfeng.
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  • ILOPERIDONE
  • US $1.00 /KG
  • CAS:133454-47-4
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 200kgs
  • 2020-03-06

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