ARANIDIPINE
86780-90-7 Basic informationMore
- Product Name:ARANIDIPINE
- Synonyms: ARANIDIPINE 2，6-Dimethyl-4-(2-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 2-oxopropyl ester MPC-1304 Sapresta 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(2-oxopropyl) ester Asanidipine 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-methyl 5-(2-oxopropyl)ester 3-Methyl 5-(2-oxopropyl) 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- CAS:86780-90-7
- MF:C19H20N2O7
- MW:388.37
- EINECS:
- Mol File:86780-90-7.mol
-
USE
Aranidipine was launched in Japan as an antihypertensive agent.
Its pharmacological effects are similar to other dihydropyridine derivatives, e.g.,
nefidipine, however, it is more potent and longer lasting. This is partially due to the
fact that its initial metabolite (ketone reduction) is just as effective as the parent
compound. Aranidipine exerts its activity by blocking Ca<sup>+2</sup> entry during depolarization
via L-type voltagegated Ca channels. This causes decreased levels of intracellular
Ca which leads to enhanced relaxation of smooth and cardiac muscle. It is a
selective α<sub>2</sub>-adrenoreceptor antagonist which inhibits vasoconstrictive responses. As
a dihydropyridine derivative, it can be synthesized via a modified Hantsch synthesis.
While sold as a racemate, the (S)-enantiomer is 150 times more active than the (R)-
antipode.
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- Company Name:Hangzhou Yuhao Chemical Technology Co., Ltd
- Tel:0571-82693216
- Products Intro:Product Name:Aranidipine
CAS:86780-90-7
More... - CB Index:52
- Related Information:Catalog(9387)
- Company Name:Shanghai Lollane Biological Technology Co.,Ltd.
- Tel:021-52996696，15000506266 15000506266
- Products Intro:Product Name:Aranidipine
CAS:86780-90-7
Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g - CB Index:55
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- Company Name:Shanghai EFE Biological Technology Co., Ltd.
- Tel:021-65675885 18964387627
- Products Intro:Product Name:MPC1304
CAS:86780-90-7
Purity:98% Package:1mg;5mg;10mg - CB Index:58
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- Company Name:Shanghai SuperLan Chemcial Technique Centre
- Tel:021-2022843681 15618226720
- Products Intro:Product Name:Aranidipine
CAS:86780-90-7
Purity:95% Package:1G,5G,10G,50G,100G,1KG - CB Index:58
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- Company Name:Beijing Solarbio Science & Tecnology Co., Ltd.
- Tel:010-50973130 4009686088
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- CB Index:68
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- Company Name:Shenzhen Regent Biochemical Technology Co., Ltd.
- Tel:0755-0755-85201366 18938635012
- Products Intro:Product Name:MPC1304
CAS:86780-90-7
Purity:>98.0% Package:10mg;100mg - CB Index:58
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- Company Name:Aikon International Limited
- Tel:025-66113011 18112977050
- Products Intro:Product Name:ARANIDIPINE
CAS:86780-90-7
Purity:95+% Package:1g;5g;10g - CB Index:58
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