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ARANIDIPINE

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USE
Aranidipine was launched in Japan as an antihypertensive agent. Its pharmacological effects are similar to other dihydropyridine derivatives, e.g., nefidipine, however, it is more potent and longer lasting. This is partially due to the fact that its initial metabolite (ketone reduction) is just as effective as the parent compound. Aranidipine exerts its activity by blocking Ca<sup>+2</sup> entry during depolarization via L-type voltagegated Ca channels. This causes decreased levels of intracellular Ca which leads to enhanced relaxation of smooth and cardiac muscle. It is a selective α<sub>2</sub>-adrenoreceptor antagonist which inhibits vasoconstrictive responses. As a dihydropyridine derivative, it can be synthesized via a modified Hantsch synthesis. While sold as a racemate, the (S)-enantiomer is 150 times more active than the (R)- antipode.
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  • Company Name:Hangzhou Yuhao Chemical Technology Co., Ltd
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    CAS:86780-90-7
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  • Company Name:Shanghai Lollane Biological Technology Co.,Ltd.
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  • Products Intro:Product Name:Aranidipine
    CAS:86780-90-7
    Purity:98% HPLC Package:5mg,10mg,50mg,100mg,1g,5g
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  • Company Name:Shanghai EFE Biological Technology Co., Ltd.
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    CAS:86780-90-7
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  • Company Name:Shanghai SuperLan Chemcial Technique Centre
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  • Products Intro:Product Name:Aranidipine
    CAS:86780-90-7
    Purity:95% Package:1G,5G,10G,50G,100G,1KG
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  • Company Name:Beijing Solarbio Science & Tecnology Co., Ltd.
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  • Company Name:Shenzhen Regent Biochemical Technology Co., Ltd.
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  • Company Name:Aikon International Limited
  • Tel:025-66113011 18112977050
  • Products Intro:Product Name:ARANIDIPINE
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    Purity:95+% Package:1g;5g;10g
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