EW-7197
1352608-82-2 Basic informationMore
- Product Name:EW-7197
- Synonyms: EW-7197 N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine NOV-1301 TEW-7197 N-[[4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methyl]-2-fluoroaniline CPD3325-A5 N-(2-Fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-1H-imidazole CPD3325
- CAS:1352608-82-2
- MF:C22H18FN7
- MW:399.42
- EINECS:
- Mol File:1352608-82-2.mol
-
USE
EW-7197 is a novel ALK-5 kinase inhibitor as well as TGF-β Type I Receptor Kinase Inhibitor. Study has shown that it can potently inhibit the breast to lung metastasis. Mice study has demonstrated that EW-7197 inhibited Smad/TGFβ signaling, cell migration, invasion, and lung metastasis in MMTV/c-Neu mice and 4T1 orthotopic-grafted mice. EW-7197 also inhibited the epithelial-to-mesenchymal transition (EMT) in both TGFβ-treated breast cancer cells and 4T1 orthotopic-grafted mice. Furthermore, EW-7197 enhanced cytotoxic T lymphocyte activity in 4T1 orthotopic-grafted mice and increased the survival time of 4T1-Luc and 4T1 breast tumor-bearing mice. It can also inhibit hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling. Therefore, it is a potential antitumor reagent.
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- Company Name:Twochem Co.Ltd
- Tel:021-021-58111628 15800915896
- Products Intro:Product Name:EW-7197
CAS:1352608-82-2
Purity:99% Package:1g;10g;100g More... - CB Index:55
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- Company Name:ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel:18149758185 18149758185
- Products Intro:Product Name:EW-7197
CAS:1352608-82-2
Purity:98% Package:10mg;100mg;1g;10g;100g;1kg Remarks:1g More... - CB Index:58
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- Company Name:Wuhan Shanhai Zhihe Biotechnology Co., Ltd.
- Tel: 17771424646
- Products Intro:Product Name:EW-7197
CAS:1352608-82-2
Purity:98% HPLC Package:10mg,50mg,100mg,500mg,1g,2g,5g - CB Index:58
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- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:Vactosertib (EW-7197
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Purity:98% HPLC Package:20mg; 50mg;100mg;500mg;1g;5g;10g - CB Index:61
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- Company Name:Finetech Industry Limited
- Tel:027-87465837 19945049750
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CAS:1352608-82-2
Purity:98% Package:1g;5g;25g;500g;1kg - CB Index:58
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- Company Name:Nanjing Chalf-Pharm Technology Co., Ltd.
- Tel:025-57018978 18251899859
- Products Intro:Product Name:EW-7197
CAS:1352608-82-2
Purity:98% - CB Index:50
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