EW-7197

• Product Name:EW-7197
• Synonyms: EW-7197 N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine NOV-1301 TEW-7197 N-[[4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methyl]-2-fluoroaniline CPD3325-A5 N-(2-Fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-1H-imidazole CPD3325
• CAS:1352608-82-2
• MF:C22H18FN7
• MW:399.42
• EINECS:
• Mol File:1352608-82-2.mol
• 

EW-7197 is a novel ALK-5 kinase inhibitor as well as TGF-β Type I Receptor Kinase Inhibitor. Study has shown that it can potently inhibit the breast to lung metastasis. Mice study has demonstrated that EW-7197 inhibited Smad/TGFβ signaling, cell migration, invasion, and lung metastasis in MMTV/c-Neu mice and 4T1 orthotopic-grafted mice. EW-7197 also inhibited the epithelial-to-mesenchymal transition (EMT) in both TGFβ-treated breast cancer cells and 4T1 orthotopic-grafted mice. Furthermore, EW-7197 enhanced cytotoxic T lymphocyte activity in 4T1 orthotopic-grafted mice and increased the survival time of 4T1-Luc and 4T1 breast tumor-bearing mice. It can also inhibit hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling. Therefore, it is a potential antitumor reagent. 

• Company Name:Twochem Co.Ltd
• Tel:021-58111628 15800915896
• Products Intro:Product Name:EW-7197
  CAS:1352608-82-2
  Purity:99% Package:1g;10g;100g More...
• CB Index:55
• Related Information:Catalog(290)

• Company Name:ShangHai Caerulum Pharma Discovery Co., Ltd.
• Tel: 18149758185
• Products Intro:Product Name:EW-7197
  CAS:1352608-82-2
  Purity:98% Package:10mg;100mg;1g;10g;100g;1kg Remarks:1g More...
• CB Index:58
• Related Information:Catalog(3421)

• Company Name:Wuhan Shanhai Zhihe Biotechnology Co., Ltd.
• Tel: 17771424646
• Products Intro:Product Name:EW-7197
  CAS:1352608-82-2
  Purity:98% HPLC Package:10mg,50mg,100mg,500mg,1g,2g,5g
• CB Index:58
• Related Information:Catalog(965)

• Company Name:Chembest Research Laboratories Limited
• Tel:021-20908456
• Products Intro:Product Name:Vactosertib (EW-7197
  CAS:1352608-82-2
  Purity:98% HPLC Package:20mg; 50mg;100mg;500mg;1g;5g;10g
• CB Index:61
• Related Information:Catalog(6011)

• Company Name:TargetMol Chemicals Inc.
• Tel:021-33632979 15002134094
• Products Intro:Product Name:Vactosertib
  CAS:1352608-82-2
  Package:1 mL;10 mg;100 mg;2 mg;200 mg;25 mg;5 mg;50 mg More...
• CB Index:58
• Related Information:Catalog(7934)

• Company Name:Finetech Industry Limited
• Tel:027-87465837 19945049750
• Products Intro:Product Name:Vactosertib
  CAS:1352608-82-2
  Purity:98% Package:1g,5g,25g,500g,1kg
• CB Index:58
• Related Information:Catalog(9636)