LY2109761
700874-71-1 Basic informationMore
- Product Name:LY2109761
- Synonyms: LY2109761/LY-2109761 LY2109761 Quinoline, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-Morpholinyl)ethoxy]- 4-[5,6-Dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinoline LY210976 4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]Morpholine N-CYCLOPENTYL-WEI -ALANINE N-CYCLOPENTYL-Β-ALANINE
- CAS:700874-71-1
- MF:C26H27N5O2
- MW:441.52
- EINECS:
- Mol File:700874-71-1.mol
-
USE
LY2109761 treatment induces a dose-dependent low-anchorage growth inhibition of L3.6pl/GLT cells, leading to ~33% or 73% inhibition at 2 μM and 20 μM, respectively, which can be strongly enhanced when combined with gemcitabine in combination index value of 0.36581. Blocking TβRI/II kinase activity with LY2109761 (5 μM) completely suppresses both the basal and TGF-β1-stimulated migration and invasion of L3.6pl/GLT cells, significantly enhances the detachment-induced apoptosis by 26% at 8 hours treatment, and completely suppresses TGF-β–induced Smad2 phosphorylation. LY2109761 treatment at 1 nM is sufficient to significantly block the migration and invasion but not adhesion of hepatocellular carcinoma cells by increasing E-cadherin expression. LY2109761 pretreatment enhances radiosensitivity of glioblastoma cells via TGF-β signaling blockage. LY2109761 (10 μM) reduces the self-renewal and proliferation of GBM-derived cancer stem–like cells (CSLC), which can be significantly enhanced when combined with radiation.
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- Company Name:Dezhou LonWel Pharmaceutical Technology Co., Ltd.
- Tel: 13761310616
- Products Intro:CAS:700874-71-1
Purity:97% HPLC Package:500mg;1g;5g;10g;100g;500g;1kg More... - CB Index:58
- Related Information:Catalog(1991)
- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:LY2109761, 98%, a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor
CAS:700874-71-1
Purity:98% Package:25MG;5MG More... - CB Index:76
- Related Information:Catalog(96815)
- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:LY2109761
CAS:700874-71-1
Remarks:C13844 More... - CB Index:61
- Related Information:Catalog(6005)