LY2109761

• Product Name:LY2109761
• Synonyms: LY2109761/LY-2109761 LY2109761 Quinoline, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-Morpholinyl)ethoxy]- 4-[5,6-Dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinoline LY210976 4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]Morpholine N-CYCLOPENTYL-WEI -ALANINE N-CYCLOPENTYL-Β-ALANINE
• CAS:700874-71-1
• MF:C26H27N5O2
• MW:441.52
• EINECS:
• Mol File:700874-71-1.mol
• 

LY2109761 treatment induces a dose-dependent low-anchorage growth inhibition of L3.6pl/GLT cells, leading to ~33% or 73% inhibition at 2 μM and 20 μM, respectively, which can be strongly enhanced when combined with gemcitabine in combination index value of 0.36581. Blocking TβRI/II kinase activity with LY2109761 (5 μM) completely suppresses both the basal and TGF-β1-stimulated migration and invasion of L3.6pl/GLT cells, significantly enhances the detachment-induced apoptosis by 26% at 8 hours treatment, and completely suppresses TGF-β–induced Smad2 phosphorylation. LY2109761 treatment at 1 nM is sufficient to significantly block the migration and invasion but not adhesion of hepatocellular carcinoma cells by increasing E-cadherin expression. LY2109761 pretreatment enhances radiosensitivity of glioblastoma cells via TGF-β signaling blockage. LY2109761 (10 μM) reduces the self-renewal and proliferation of GBM-derived cancer stem–like cells (CSLC), which can be significantly enhanced when combined with radiation.

• Company Name:AdooQ Bioscience CHINA
• Tel:025-58849295 18951903616;
• Products Intro:Product Name:LY2109761
  CAS:700874-71-1
  Purity:0.98 Package:1mg;5mg;10mg;25mg;50mg;100mg More...
• CB Index:60
• Related Information:Catalog(2989)

• Company Name:Dezhou LonWel Pharmaceutical Technology Co., Ltd.
• Tel: 13761310616
• Products Intro:CAS:700874-71-1
  Purity:97% HPLC Package:500mg;1g;5g;10g;100g;500g;1kg More...
• CB Index:58
• Related Information:Catalog(1948)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:LY2109761, 98%, a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor
  CAS:700874-71-1
  Purity:98% Package:25MG;5MG More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:Chembest Research Laboratories Limited
• Tel:021-20908456
• Products Intro:Product Name:LY2109761
  CAS:700874-71-1
  Remarks:C13844 More...
• CB Index:61
• Related Information:Catalog(6011)