Pertuzumab
380610-27-5 Basic informationMore
- Product Name:Pertuzumab
- Synonyms: pertuzumab 2C4 Immunoglobulin G1, anti-(human V (receptor)) (human-mouse monoclonal 2C4 heavy chain), disulfide with human-mouse monoclonal 2C4 kappa-chain, dimer Omnitarg Unii-K16aiq8ctm Pertuzumab (anti-HER2) Pertuzumab-Perjeta Research Grade Pertuzumab(DHC09602)
- CAS:380610-27-5
- MF:C17H27NO2
- MW:277.40178
- EINECS:
- Mol File:380610-27-5.mol
-
USE
Pertuzumab is an anti-human epidermal growth factor receptor 2 (HER2) antibody that was approved by the US FDA in June 2012 for use in combination with trastuzumab (Herceptin?) and docetaxel chemotherapy for the treatment of people with HER2-positive (HER2<sup>+</sup>) metastatic breast cancer (mBC) who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease. Pertuzumab inhibits HER2 dimer formation with other HER members, such as HER1 and HER3, thus inhibiting the downstream signaling processes associated with tumor growth and progression. Pertuzumab is the first HER2 dimerization inhibitor to reach the market. The mechanism of actions of trastuzumab and pertuzumab are believed to complement each other and provide a more comprehensive inhibition of tumor growth than either agent alone. Preclinical data showed that the combination of trastuzumab and pertuzumab has a strongly enhanced antitumor effect and induces tumor regression in xenograft models, something that cannot be achieved by either monotherapy alone.
Lastest Price from Pertuzumab manufacturers
- Pertuzumab
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- US $0.00-0.00/mg
- CAS:380610-27-5
- Min. Order: 5mg
- Purity: 99%
- Supply Ability: 50KG
- 2022-04-21
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- Company Name:Wuhan Sunrise Technology Development Co., Ltd.
- Tel:27-027-83314682 13554138826
- Products Intro:Product Name:pertuzuMab
CAS:380610-27-5
Purity:97% (API) Package:2mg/vial ， for other packages pls just contact for details More... - CB Index:62
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- Tel:0411-62910999 13889544652
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- Company Name:Nanjing Sunlida Biological Technology Co., Ltd.
- Tel:025-57798810
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Purity:98% Package:1g;5g;25g;100g - CB Index:55
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- Company Name:ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel:18149758185 18149758185
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- Company Name:Taizhou KEDE Chemical Co., Ltd
- Tel:0576-84613060 13093829633
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CAS:380610-27-5
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