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Tolvaptan

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150683-30-0 Basic informationMore
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Tolvaptan(SAMSCA) should be initiated and re-initiated in patients only in a hospital where serum sodium can be monitored closely. Too rapid correction of hyponatremia (e.g., &gt;12 mEq/L/24 hours) can cause osmotic demyelination resulting in dysarthria, mutism, dysphagia, lethargy, affective changes, spastic quadriparesis, seizures, coma and death. In susceptible patients, including those with severe malnutrition, alcoholism or advanced liver disease, slower rates of correction may be advisable.<br /> Tolvaptan(SAMSCA) is contraindicated in the following conditions:<br /> <br /> <ul> <li>Urgent need to raise serum sodium acutely</li> <li>Inability of the patient to sense or appropriately respond to thirst</li> <li>Hypovolemic hyponatremia</li> <li>Concomitant use of strong CYP 3A inhibitors</li> <li>Anuric patients</li> <li>Hypersensitivity (e.g. anaphylactic shock, rash generalized) to tolvaptan or its components</li> </ul>
Lastest Price from Tolvaptan manufacturers
  • Tolvaptan
  • US $0.00-0.00/kg
  • CAS:150683-30-0
  • Min. Order: 1kg
  • Purity: 99.5%
  • Supply Ability: 5000
  • 2024-04-26
  • Tolvaptan
  • US $28.00-13.00/kg
  • CAS:150683-30-0
  • Min. Order: 1kg
  • Purity: 99.9%
  • Supply Ability: 50000 tons
  • 2024-04-10

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