Bulaquine

• Product Name:Bulaquine
• Synonyms: compound 80-53 1-[4,5-Dihydro-2-[[4-[(6-methoxyquinoline-8-yl)amino]pentyl]amino]furan-3-yl]ethanone CDRI-80/53 N-[(3-Acetyl-4,5-dihydrofuran)-2-yl]-N'-(6-methoxy-8-quinolinyl)-1,4-pentanediamine Bulaquine 2(3H)-Furanone, dihydro-3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]- aablaquine
• CAS:79781-00-3
• MF:C21H27N3O3
• MW:369.46
• EINECS:
• Mol File:79781-00-3.mol
• 

Bulaquine is a derivative of primaquine that was introduced in India in combination with chloroquine as a treatment against malaria. The compound is prepared by condensation of primaquine with 3-acetyl-y-butyrolactone in presence of a catalytic amount of base. Bulaquine kills the latent tissue stage (hypnozoites) of the parasite Plasmodium vivax accumulated in the liver and responsible for relapses. Its efficient anti-relapse activity was demonstrated against sporozoite induced Plasmodium cynomolgi infection in rhesus monkey. Bulaquine is safer than primaquine, the preceding candidate against malaria relapse. Although it is stable at pH 7-8, bulaquine is hydrolyzed to primaquine under acidic conditions.

• Company Name:TargetMol Chemicals Inc.
• Tel: 15002134094
• Products Intro:Product Name:Bulaquine
  CAS:79781-00-3
  Package:50mg/RMB 13800;100mg/RMB 17500;25mg/RMB 10600
• CB Index:58
• Related Information:Catalog(19699)