CC-223
1228013-30-6 Basic informationMore
- Product Name:CC-223
- Synonyms: CC-223 7-[6-(2-Hydroxypropan-2-yl)pyridin-3-yl]-1-(trans-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one Pyrazino[2,3-b]pyrazin-2(1H)-one, 3,4-dihydro-7-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-(trans-4-methoxycyclohexyl)- Onatasertib 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((1r,4r)-4-methoxycyclohexyl)-3,4-dihydropyrazino-[2,3-b]pyrazin-2(1H)-one CS-2163 CS-2039 CC223;CC 223
- CAS:1228013-30-6
- MF:C21H27N5O3
- MW:397.47
- EINECS:
- Mol File:1228013-30-6.mol
-
USE
CC-223 is a potent, selective, and orally bioavailable inhibitor of mTOR kinase, demonstrating inhibition of mTORC1 (pS6RP and p4EBP1) and mTORC2 [pAKT(S473)] in cellular systems. After tumor-bearing mice was treated with CC-223 for a single oral dose. It exhibited dose-dependent tumor growth inhibition in multiple solid tumor xenografts. The observed antitumor activity of CC-223 is likely to be mediated through inhibition of both mTORC1 and mTORC2. CC-223 is currently in phase I clinical trials for its treatment of advanced solid and hematologic cancers.
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- Company Name:ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel:18149758185 18149758185
- Products Intro:Product Name:CC-223
CAS:1228013-30-6
Purity:98% Package:10mg;100mg;1g;10g;100g;1kg - CB Index:58
- Related Information:Catalog(3466)
- Company Name:HangZhou YuHao Chemical Technology Co., Ltd.
- Tel:0571-82693216
- Products Intro:Product Name:CC-223
CAS:1228013-30-6
Purity:98% Package:1g; 10g; 100g - CB Index:58
- Related Information:Catalog(2028)
- Company Name:Shanghai Lollane Biological Technology Co.,Ltd.
- Tel:021-52996696，15000506266 15000506266
- Products Intro:Product Name:CC-223
CAS:1228013-30-6
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G More... - CB Index:55
- Related Information:Catalog(4573)
- Company Name:Shanghaizehan biopharma technology co., Ltd.
- Tel:021-61350663 13052117465
- Products Intro:Product Name:Onatasertib(CC 223,ATG-008)
CAS:1228013-30-6
Purity:98% Package:1g/;5g/ - CB Index:55
- Related Information:Catalog(1005)