VX-770
873054-44-5 Basic informationMore
- Product Name:VX-770
- Synonyms: Ivacaftor, >=98% 3-QuinolinecarboxaMide, N-[2,4-bis(1,1-diMethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo- N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide VX 770, Ivacaftor Ivacaftor-D4 VX-770(Ivacattor) IVACAFTOR (VX-770);VX 770 N-(2,4-DITERT-BUTYL-5-HYDROXYPHENYL)-4-OXO-1H-QUINOLINE-3-CARBOXAMIDE
- CAS:873054-44-5
- MF:C24H28N2O3
- MW:392.49
- EINECS:
- Mol File:873054-44-5.mol
USE
In January 2012, the US FDA approved ivacaftor for the treatment of cystic
fibrosis (CF) in patients who have the G551D mutation of the CF transmembrane regulator (CFTR) and are at least 6 years old. Ivacaftor (also known as VX-770) is a CFTR potentiator that increases the open probability of CFTR, thus increasing chloride
secretion particularly in the 5% of CF patients with the G551D/F508 gating/
processing mutation. Ivacaftor was discovered by medicinal chemistry optimization of a lead scaffold identified through high-throughput screening of a 228,000 compound collection. In cultured bronchial epithelial cells from a CF patient with F508del, ivacaftor increased chloride secretion
(EC<sub>50</sub>=81 nM). Preparation of ivacaftor is accomplished via a multistep
synthesis oftwointermediates, 4-oxo-1,4-dihydroquinoline-3-carboxylic acid
and 5-amino-di-tert-butylphenyl methyl carbonate, which are coupled using
propane phosphonic acid anhydride (T3P) to afford the amide; deprotection of
the phenol then provides ivacaftor.
Lastest Price from VX-770 manufacturers
- Ivacaftor
- US $15.00-10.00/KG
- CAS:873054-44-5
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 2021-07-13
- Ivacaftor
- US $15.00-10.00/KG
- CAS:873054-44-5
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 2021-07-10
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- Company Name:ShangHai Onsyn-Chemical Technology Co., Ltd.
- Tel:021-58359326 13124831025
- Products Intro:Product Name:VX 770, Ivacaftor
CAS:873054-44-5
Purity:99% Package:1g, 10g, 100g, 1kg More... - CB Index:55
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- Company Name:Shijiazhuang Dingmin pharmaceutical Sciences Co.,Ltd
- Tel:0311-67591193 15030197620
- Products Intro:Product Name:Ivacaftor (VX-770)
CAS:873054-44-5
Purity:99%+ Package:1kg/ Remarks:kg - CB Index:58
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- Company Name:Luan lingxi Chemical Products Co., Ltd
- Tel: 18712378369
- Products Intro:Product Name:N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3- quinolinecarboxamide
CAS:873054-44-5
Purity:0.99 Package:250g;500g;1kg;5kg - CB Index:58
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- Company Name:Henan Dobe Chemical Co. , Ltd.
- Tel:0370-6999054 17550097782
- Products Intro:Product Name:2,4-DI-TERT-BUTYL-5-HYDROXYPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMID
CAS:873054-44-5
Purity:99% HPLC Package:1kg 25kg 200kg 1000kg - CB Index:58
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- Company Name:Suzhou Kangda Pharmaceutical Co., Ltd
- Tel:18912614918 18912614918
- Products Intro:Product Name:VX-770
CAS:873054-44-5
Purity:99.60% Package:1;10;100;1000 - CB Index:58
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- Company Name:Hangzhou Xinbaisi Biomedical Co., Ltd.
- Tel: 13325818654
- Products Intro:Product Name:Ivacaftor
CAS:873054-44-5
Purity:98% Package:5g;100g;1kg;100kg More... - CB Index:58
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- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:Ivacaftor
CAS:873054-44-5
Package:25MG;5MG More... - CB Index:76
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