Ivacaftor

• Product Name:Ivacaftor
• Synonyms: Ivacaftor, >=98% 3-QuinolinecarboxaMide, N-[2,4-bis(1,1-diMethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo- N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide VX 770, Ivacaftor Ivacaftor-D4 VX-770(Ivacattor) IVACAFTOR (VX-770);VX 770 N-(2,4-DITERT-BUTYL-5-HYDROXYPHENYL)-4-OXO-1H-QUINOLINE-3-CARBOXAMIDE
• CAS:873054-44-5
• MF:C24H28N2O3
• MW:392.49
• EINECS:
• Mol File:873054-44-5.mol
• 

In January 2012, the US FDA approved ivacaftor for the treatment of cystic fibrosis (CF) in patients who have the G551D mutation of the CF transmembrane regulator (CFTR) and are at least 6 years old. Ivacaftor (also known as VX-770) is a CFTR potentiator that increases the open probability of CFTR, thus increasing chloride secretion particularly in the 5% of CF patients with the G551D/F508 gating/ processing mutation. Ivacaftor was discovered by medicinal chemistry optimization of a lead scaffold identified through high-throughput screening of a 228,000 compound collection. In cultured bronchial epithelial cells from a CF patient with F508del, ivacaftor increased chloride secretion (EC₅₀=81 nM). Preparation of ivacaftor is accomplished via a multistep synthesis oftwointermediates, 4-oxo-1,4-dihydroquinoline-3-carboxylic acid and 5-amino-di-tert-butylphenyl methyl carbonate, which are coupled using propane phosphonic acid anhydride (T3P) to afford the amide; deprotection of the phenol then provides ivacaftor.

• Ivacaftor
• 
• US $0.00 /g
• CAS:873054-44-5
• Min. Order: 1g
• Purity: More Than 99%
• Supply Ability: 100kg/Month
• 2025-01-13

• Ivacaftor
• 
• US $15.00-10.00/KG
• CAS:873054-44-5
• Min. Order: 1KG
• Purity: 99%+ HPLC
• Supply Ability: Monthly supply of 1 ton
• 2021-07-13

• Company Name:ShangHai Onsyn-Chemical Technology Co., Ltd.
• Tel:021-58359326 13124831025
• Products Intro:Product Name:VX 770, Ivacaftor
  CAS:873054-44-5
  Purity:99% Package:1g, 10g, 100g, 1kg More...
• CB Index:55
• Related Information:Catalog(246)

• Company Name:Shijiazhuang Dingmin pharmaceutical Sciences Co.,Ltd
• Tel:0311-67591193 15030197620
• Products Intro:Product Name:Ivacaftor (VX-770)
  CAS:873054-44-5
  Purity:99%+ Package:1kg/ Remarks:kg
• CB Index:58
• Related Information:Catalog(300)

• Company Name:Changzhou Jiezhan Chemical Technology Co., Ltd
• Tel:15861130028; 15861130028
• Products Intro:Product Name:N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3- quinolinecarboxamide
  CAS:873054-44-5
  Purity:0.99 Package:250g;500g;1kg;5kg
• CB Index:58
• Related Information:Catalog(288)

• Company Name:Hangzhou Xinbaisi Biomedical Co., Ltd.
• Tel: 13325818654
• Products Intro:Product Name:Ivacaftor
  CAS:873054-44-5
  Purity:98% Package:5g;100g;1kg;100kg More...
• CB Index:58
• Related Information:Catalog(240)

• Company Name:Shanghai Enong Biotechnology Co., LTD
• Tel:+86-15821616017 +86-15821616017
• Products Intro:Product Name:VX-770
  CAS:873054-44-5
  Purity:99% Package:1g;100g;1kg;10kg;100kg
• CB Index:58
• Related Information:Catalog(108)

• Company Name:Hangzhou Yinghui Industrial Co.,Ltd
• Tel: 15355417531
• Products Intro:Product Name:VX-770
  CAS:873054-44-5
  Purity:99 Package:500g;1000g
• CB Index:58
• Related Information:Catalog(67)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Ivacaftor
  CAS:873054-44-5
  Package:25MG;5MG More...
• CB Index:76
• Related Information:Catalog(96815)