Pomalidomide

• Product Name:Pomalidomide
• Synonyms: 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione Pomalidomide Pomalidomide(CC-4047) ActiMid 1H-Isoindole-1,3(2H)-dione,4-aMino-2-(2,6-dioxo-3-piperidinyl)- Pomalidomide(CC-4047,Actimid) 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide
• CAS:19171-19-8
• MF:C13H11N3O4
• MW:273.24
• EINECS:805-902-5
• Mol File:19171-19-8.mol
• 

In February 2013, the US FDA approved pomalidomide (also known as CC4047) for the treatment of multiple myeloma (MM) in patients with disease progression after receiving other cancer therapeutics. Pomalidomide is a 4-amino analog of thalidomide with enhanced potency and an improved toxicity profile. Pomalidomide and thalidomide exert their effects by modulation of immunity, inhibition of angiogenesis, interference with the bone/tumor microenvironment, and inhibition of the cereblon protein. Pomalidomide potently inhibited in vitro proliferation in a variety of human MM cell lines, IC₅₀～10 nM, while thalidomide showed almost no inhibition up to 100 μM. In mouse MM tumor models, 50 mg/kg daily doses of pomalidomide resulted in marked inhibition of tumor growth after 15 days of treatment and complete regression in 3–6 weeks versus thalidomide-treated controls at the same dose. Pomalidomide is prepared by condensation of 4-nitrophthalic anhydride with 3-aminopiperidine-2,6-dione followed by catalytic hydrogenation of the nitro group.

• Pomalidomide
• 
• US $0.00 /Kg/Bag
• CAS:19171-19-8
• Min. Order: 10g
• Purity: 99%min HPLC
• Supply Ability: 10KGS
• 2024-11-22

• Pomalidomide
• 
• US $0.00 /g
• CAS:19171-19-8
• Min. Order: 1g
• Purity: 98% HPLC
• Supply Ability: 100kg
• 2024-11-19

• Company Name:shandong XuanHong Pharmaceutical Technology Co.,Ltd
• Tel:0531-88801869 15562622698
• Products Intro:Product Name:Pomalidomide
  CAS:19171-19-8
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• CB Index:55
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• Company Name:Hebei mo Jin biotechnology co., ltd
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• Products Intro:Product Name:Pomalidomide
  CAS:19171-19-8
  Purity:99% Package:25kg/
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• Company Name:Chongqing Botao Biotechnology Co., LTD
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  CAS:19171-19-8
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• Company Name:Jiangxi taisinor Co., Ltd.
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• Products Intro:Product Name:Pomalidomide
  CAS:19171-19-8
  Purity:HPLC>99.5% Package:1kg;25kg;100kg
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• Company Name:Jinan Shengqi Pharmaceutical Co., Ltd
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  CAS:19171-19-8
  Purity:99%
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• Company Name:J & K SCIENTIFIC LTD.
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• Products Intro:Product Name:Pomalidomide, 99%, a inhibitor of TNF-α
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• Company Name:Chembest Research Laboratories Limited
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• Products Intro:Product Name:Pomalidomide(CC-4047)
  CAS:19171-19-8
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