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19171-19-8

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In February 2013, the US FDA approved pomalidomide (also known as CC4047) for the treatment of multiple myeloma (MM) in patients with disease progression after receiving other cancer therapeutics. Pomalidomide is a 4-amino analog of thalidomide with enhanced potency and an improved toxicity profile. Pomalidomide and thalidomide exert their effects by modulation of immunity, inhibition of angiogenesis, interference with the bone/tumor microenvironment, and inhibition of the cereblon protein. Pomalidomide potently inhibited in vitro proliferation in a variety of human MM cell lines, IC<sub>50</sub>~10 nM, while thalidomide showed almost no inhibition up to 100 μM. In mouse MM tumor models, 50 mg/kg daily doses of pomalidomide resulted in marked inhibition of tumor growth after 15 days of treatment and complete regression in 3–6 weeks versus thalidomide-treated controls at the same dose. Pomalidomide is prepared by condensation of 4-nitrophthalic anhydride with 3-aminopiperidine-2,6-dione followed by catalytic hydrogenation of the nitro group.
Lastest Price from Pomalidomide manufacturers
  • Pomalidomide
  • US $80.00 /KG/Tin
  • CAS:19171-19-8
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10Tons
  • 2022-01-19

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  • Company Name:shandong XuanHong Pharmaceutical Technology Co.,Ltd
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  • Company Name:Chembest Research Laboratories Limited
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