metreleptin

• Product Name:metreleptin
• Synonyms: Metreleptin impurity A metreleptin
• CAS:186018-45-1
• MF:
• MW:0
• EINECS:
• Mol File:Mol File
• 

Metreleptin was approved by the Japanese Ministry of Health, Labor and Welfare in March 2013 for the treatment of lipodystrophy and by the US FDA in February 2014 for the treatment of generalized lipodystrophy. Metreleptin is a recombinant N-methionyl analog of the leptin protein; leptin itself was identified via positional cloning in studies on the cause of obesity in the ob/ob mouse strain, which lacks the leptin gene. While there have been many studies of leptin in obesity, this first approval of a leptin analog is directed toward the treatment of lipodystrophy. Toward that end, the effects of leptin administration were studied in a transgenic mouse model of lipodystrophy (with constitutive activation of sterol-regulatory-element-binding-protein- 1c) that results in lack of white adipose tissue. Since, adipocytes serve as a storage depot for triglycerides (TG), the lack of adipocytes results in ectopic lipid deposition in organs such as liver causing hepatomegaly and severe insulin resistance.

• Company Name:S.Z. PhyStandard Bio-Tech. Co., Ltd.
• Tel:0755-83725681-603
• Products Intro:Product Name:Metreleptin impurity A
  CAS:186018-45-1
  Purity:99% HPLC Package:10mg/25mg/50mg/100mg More...
• CB Index:50
• Related Information:Catalog(4484)

• Company Name:Beijing HuaMeiHuLiBiological Chemical
• Tel:010-56205725
• Products Intro:Product Name:Metreleptin
  CAS:186018-45-1
  Purity:99% Package:25kg More...
• CB Index:58
• Related Information:Catalog(12323)

• Company Name:Shanghai YuanYe Biotechnology Co., Ltd.
• Tel: 18916372613
• Products Intro:Product Name:metreleptin
  CAS:186018-45-1
  Package:500μg;1mg Remarks:K21714
• CB Index:60
• Related Information:Catalog(87240)

• Company Name:Guangzhou TongYi biochemistry technology Co.,LTD
• Tel:
• Products Intro:Product Name:Metreleptin
  CAS:186018-45-1
  Purity:99% Package:1g,10g,100g,500g,1kg,25kg,100kg,500kg
• CB Index:58
• Related Information:Catalog(2988)

• Company Name:AFINE CHEMICALS LIMITED
• Tel:+86-571-85134551 +86-18958018566
• Products Intro:Product Name:METRELEPTIN
  CAS:186018-45-1
  Purity:98%+ Package:Standard or custom package Remarks:excellent quality and reliable supplier
• CB Index:58
• Related Information:Catalog(15111)

• Company Name:Henan Tianfu Chemical Co.,Ltd.
• Tel:+86-0371-55170693 +86-19937530512
• Products Intro:Product Name:metreleptin
  CAS:186018-45-1
  Purity:99% Package:25KG;5KG;1KG
• CB Index:55
• Related Information:Catalog(21533)