curvularin
10140-70-2 Basic informationMore
- Product Name:curvularin
- Synonyms: curvularin 2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-,(4S)- S-Curvularin, NSC 166071 (S)-Curvularin (-)-Curvularin
- CAS:10140-70-2
- MF:C16H20O5
- MW:292.33
- EINECS:
- Mol File:10140-70-2.mol
-
USE
Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species, including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway. This action offers an approach to the development of drugs inhibiting iNOS overproduction associated with NO pathophysiology.
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- Company Name:Shanghai EFE Biological Technology Co., Ltd.
- Tel:021-65675885 18964387627
- Products Intro:Product Name:Curvularin
CAS:10140-70-2
Purity:98% Package:1mg;5mg More... - CB Index:58
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- Company Name:Lynnchem
- Tel:86-(0)29-85992781 17792393971
- Products Intro:Product Name:curvularin
CAS:10140-70-2
Purity:>99% by HPLC Package:1mg;5mg More... - CB Index:58
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- Company Name:Shenzhen Polymeri Biochemical Technology Co., Ltd.
- Tel:+86-400-002-6226 +86-13028896684;
- Products Intro:Product Name:Curvularin
CAS:10140-70-2
More... - CB Index:58
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- Company Name:Career Henan Chemica Co
- Tel:+86-0371-86658258 +8613203830695
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CAS:10140-70-2
Purity:Min98% HPLC/GC Package:1KG;1USD - CB Index:58
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- Company Name:BioBioPha Co., Ltd.
- Tel:0871-65217109
- Products Intro:Product Name:Curvularin
CAS:10140-70-2
Purity:98.0% Package:5mg; 10mg; 20mg - CB Index:58
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- Company Name:Shaanxi Dideu Medichem Co. Ltd
- Tel:029-81145920 13259709322
- Products Intro:Product Name:curvularin
CAS:10140-70-2
Purity:98% - CB Index:58
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