Taltirelin

• Product Name:Taltirelin
• Synonyms: Taltirelin interMediate (4S)-Hexahydro-1-Methyl-2,6-dioxo-4-pyriMidinecarbonyl-L-histidyl- Ceredist, TA-0910 TALTIRELIN INTERMEDIATES Taltirelin Acetate,TA-0910 Taltirelin L-Prolinamide, N-[(hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-, (S)- L-Prolinamide, N-[[(4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl- (9CI)
• CAS:103300-74-9
• MF:C17H23N7O5
• MW:405.41
• EINECS:
• Mol File:103300-74-9.mol
• 

Taltirelin was marketed in Japan for the treatment of neurodegenerative diseases, in particular the improvement of ataxia due to spino-cerebellar degeneration (SCD); it is the first orally-active drug in this indication. This synthetic thyrotropin-releasing hormone (TRH) analog is prepared by condensation of (S)-1-methyl-4,5-dihydroorotic acid with L-histidyl-Lprolinamide. It was shown that the S-configuration for all 3 chiral centers is crucial for CNS activity. Taltirelin is a potent agonist of the TRH receptors that shows significant effects on the cerebral monoamine systems when administered i.p. in rats. As TRH at 10-fold higher doses, taltirelin has been found to increase the extracellular levels of dopamine and its metabolites (DOPAC and HVA) as well as precursors and/or metabolites of noradrenaline and serotonin in different areas of the rat brain. Taltirelin produced an anti-ataxic activity in the Rolling mouse Nagoya, an ataxic mutant mouse. In several clinical studies performed in patients suffering from various forms of SCD, taltirelin demonstrated a statistically significant increase in the global improvement of ataxic symptoms and other neurologic abnormalities.

• Taltirelin
• 
• US $25.00-15.00/box
• CAS:103300-74-9
• Min. Order: 1box
• Purity: 99.9%
• Supply Ability: 200tons/year
• 2024-01-17

• Taltirelin
• 
• US $0.00 /MG
• CAS:103300-74-9
• Min. Order: 10MG
• Purity: 99%
• Supply Ability: 20 TONS
• 2023-11-27

• Company Name:Hangzhou Sinoda Pharmaceutical Technology Co. LTD
• Tel: 17306812703
• Products Intro:Product Name:Taltirelin
  CAS:103300-74-9
  Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
• CB Index:58
• Related Information:Catalog(5949)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Taltirelin
  CAS:103300-74-9
  Package:100Mg,10Mg More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
• Tel:821-50328103-801 18930552037
• Products Intro:Product Name:Taltirelin;N-[[(4S)-Hexahydro-1-Methyl-2,6-dioxo-4-pyriMidinyl]carbonyl]-L-histidyl-L-prolinaMide
  CAS:103300-74-9
  Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More...
• CB Index:69
• Related Information:Catalog(15848)

• Company Name:Chembest Research Laboratories Limited
• Tel:021-20908456
• Products Intro:Product Name:Taltirelin
  CAS:103300-74-9
  Remarks:C14212 More...
• CB Index:61
• Related Information:Catalog(6011)