Trimetrexate
52128-35-5 Basic informationMore
- Product Name:Trimetrexate
- Synonyms: Trimetrexate 5-Methyl-6-(3,4,5-trimethoxyanilinomethyl)quinazoline-2,4-diamine 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine CI-898 2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]- 5-Methyl-6-{[(3,4,5-triMethoxyphenyl)aMino]Methyl}quinazoline-2,4-diaMine NSC249008 CI-898; CI 898; CI898
- CAS:52128-35-5
- MF:C19H23N5O3
- MW:369.42
- EINECS:
- Mol File:52128-35-5.mol
-
USE
The drug is available as a lyophilized powder in 5- or 30-mgvials for IV use. The drug is used to treat colorectal cancer,head and neck cancer as well as NSCLC. The mechanism ofaction of trimetrexate involves folate antagonism and inhibitionof thymidylate synthesis. Trimetrexate does not formintracellular polyglutamate adducts as does methotrexateand other related compounds. Resistance can occur by increasedexpression of the target enzyme, decreased bindingaffinity for the target enzyme, or decreased intracellulardrug transport. Trimetrexate is administered only by the IVroute and distributed throughout the body with extensivebinding to plasma proteins. The major catabolic pathwaysinvolve O-demethylation followed by glucuronide conjugation.The drug interaction and toxicity profiles are similar tothose for methotrexate.
Lastest Price from Trimetrexate manufacturers
- Trimetrexate
-
- US $15.00-10.00/KG
- CAS:52128-35-5
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 2021-07-13
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- Company Name:ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel:18149758185 18149758185
- Products Intro:Product Name:Trimetrexate
CAS:52128-35-5
Purity:98% Package:1g;10g;100g - CB Index:58
- Related Information:Catalog(3466)
- Company Name:Shanghai Synchem Pharma Co., ltd
- Tel:21-619849051-1 18521059765
- Products Intro:Product Name:Trimetrexate
CAS:52128-35-5
Purity:98%+ Package:500g,1kg,10kg or as requested More... - CB Index:55
- Related Information:Catalog(6463)
- Company Name:Amadis Chemical Company Limited
- Tel:571-89925085
- Products Intro:Product Name:Trimetrexate
CAS:52128-35-5
Purity:0.97 Package:mgs,gs,kgs Remarks:A913386 - CB Index:58
- Related Information:Catalog(131957)
- Company Name:Beijing Jin Ming Biotechnology Co., Ltd.
- Tel:010-60605840 18892239720
- Products Intro:Product Name:Trimetrexate
CAS:52128-35-5
Purity:98% Package:5mg;10mg - CB Index:58
- Related Information:Catalog(12306)
- Company Name:Baoji Guokang Bio-Technology Co., Ltd.
- Tel:0917-3909592 13892490616
- Products Intro:Product Name:Trimetrexate
CAS:52128-35-5
Purity:0.99 Package:5KG;1KG - CB Index:58
- Related Information:Catalog(9314)
- Company Name:DC Chemicals
- Tel:021-58447131 13564518121
- Products Intro:Product Name:Trimetrexate
CAS:52128-35-5
Purity:98% HPLC Package:100mg，250mg，1g - CB Index:58
- Related Information:Catalog(9409)
- Company Name:ChemeGen(Shanghai) Biotechnology Co.,Ltd.
- Tel: 18818260767
- Products Intro:Product Name:Trimetrexate
CAS:52128-35-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g - CB Index:58
- Related Information:Catalog(11217)