PEROSPIRONE
150915-41-6 Basic informationMore
- Product Name:PEROSPIRONE
- Synonyms: PEROSPIRONE PEROSPIRONE HCL 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, (3aR,7aS)-rel- (9CI) 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, cis- cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cyclohexanedicarboximide Perospirine (1R,2S)-N-[4-[4-(1,2-Benzisothiazole-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarbimide (3aα,7aα)-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H-isoindole-1,3(2H)-dione
- CAS:150915-41-6
- MF:C23H30N4O2S
- MW:426.57
- EINECS:
- Mol File:150915-41-6.mol
-
USE
Perospirone hydrochloride was launched in Japan as a new treatment of schizophrenia
and other psychoses. This structurally-related analog of ziprasidone can be classically
prepared by alkylation of 1-(3-benzisothiazolyl)-piperazine with the appropriate N-
(chlorobutyl)-succinimide. As a result of an in vitro determination of its binding profile,
perospirone demonstrated a high affinity for 5-HT<sub>2</sub>, 5-HT<sub>1A</sub> and D<sub>2</sub> receptors as well as a
significant but lower affinity for DI and al receptors. Interestingly, these differential effects
on neurotransmitters with a high in vivo occupancy of 5-HT<sub>2A</sub> receptors with lower D<sub>2</sub>
occupancy seems to provide this new agent with a significantly lower propensity for the
development of extrapyramidal symptoms (EPS) and tardive schizophrenia, the main sideeffects
associated with classical antipsychotic therapy. Furthermore, perospirone exhibited
anxiolytic-like effects in animal models. A long-term clinical trial (> 6 months) in a group of
patients suffering from schizophrenia demonstrated the efficacy of perospirone over
placebo for the treatment of the positive, negative and general symptoms of schizophrenia
at doses of 12 mg to 96 mg t.i.d.
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- Company Name:Henan Vcommend Consultrading Co., Ltd.
- Tel: 13393721940
- Products Intro:Product Name:Perospirone HCL
CAS:150915-41-6
Purity:98.0% Package:25kg/drum - CB Index:58
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- Company Name:Daicel Chiral Technologies (China)CO.,LTD
- Tel:021-50460086-9 15921403865
- Products Intro:Product Name:Perospirone-D8
Purity:95% HPLC Package:10mg ;25mg;50mg;100mg Remarks:DCTI-A-247 - CB Index:65
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- Company Name:ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel:18149758185 18149758185
- Products Intro:Product Name:Perospirone
CAS:150915-41-6
Purity:98% Package:1g;10g;100g - CB Index:58
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- Company Name:Suzhou yacoo science co.,Ltd
- Tel:0512-87182056 18013166090
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CAS:150915-41-6
Purity:98% Package:10g;50g;1kg;5Kg;25kg; - CB Index:60
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- Company Name:Wuxi MinHua Biochem Pharmatech Co.,Ltd.
- Tel:0510-0510-66903969 13961776301
- Products Intro:Product Name:Perospirone
CAS:150915-41-6
Purity:97% Package:5g;10g More... - CB Index:58
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- Company Name:ShangHai Biochempartner Co.,Ltd
- Tel:177-54423994 17754423994
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CAS:150915-41-6
Purity:98% HPLC LCMS Package:100mg;1g More... - CB Index:62
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- Company Name:Shanghai Chaolan Chemical Technology Center
- Tel:QQ:65489617 15618227136
- Products Intro:Product Name:Perospirone
CAS:150915-41-6
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G - CB Index:58
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