Neratinib

• Product Name:Neratinib
• Synonyms: Neratinib(HKI-272) (2E)-N-[4-[[3-chloro-4-(2-pyridinylMethoxy)phenyl]aMino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(diMethylaMino)-2-butenaMide neratinib (E)-N-[4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide N-(4-(3-Chloro-4-(2-pyridinylmethoxy)anilino)-3-cyano-7-ethoxy-6-quinolyl)-4-(dimethylamino)-2-butenamide Unii-jjh94R3pwb (2e)-n-(4-((3-chloro-4-((pyridin-2-yl)Methoxy)phenyl)aMino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(diMethylaMino)but-2-enaMide neratinib HKI-272 Neratinib
• CAS:698387-09-6
• MF:C30H29ClN6O3
• MW:557.04
• EINECS:811-237-1
• Mol File:698387-09-6.mol
• 

Neratinib developed by US Wyeth company is an irreversible epidermal growth factor receptor(EGFR) inhibitor. It is a multiple target point of small molecule tyrosine kinase inhibitors to HER 2 and HER1 after Lapatinib, and is an irreversible ErbB receptor tyrosine kinase inhibitor. Neratinib could selectively inhibit HER-1 and HER-2 of EGFR family(IC50 was 92 nmol/L and 59 nmol/L, respectively). Clinical research showed that Neratinib exerted significant therapeutic effect on non-small cell lung cancer, colon cancer, and breast cancer. <br/> The phaseⅡclinical trial indicated that Neratinib showed good efficacy and tolerance to HER-2 positive patients with advanced breast cancer who had been received or not Trastuzumab treatment.<br/> The phase Ⅲ breast cancer clinical trial was complete in September 2014. The data indicated that the efficacy of Neratinib was better than Roche's Herceptin in treatment of HER-2 positive early breast cancer.<br/> The above information is edited by the Chemicalbook of Liu Yujie.

• Neratinib
• 
• US $0.00-0.00/kg
• CAS:698387-09-6
• Min. Order: 1kg
• Purity: 99%，single impurity＜0.1
• Supply Ability: 1 ton
• 2024-11-26

• Neratinib (HKI-272)
• 
• US $0.00 /g
• CAS:698387-09-6
• Min. Order: 1g
• Purity: 98% HPLC
• Supply Ability: 1KG
• 2024-11-19

• Company Name:Shanghai jing Hao pharmaceutical technology co., LTD
• Tel:021-68900963 15618693615
• Products Intro:Product Name:Neratinib
  CAS:698387-09-6
  Purity:99.0% Package:100kg;1kg;10kg Remarks:1g More...
• CB Index:58
• Related Information:Catalog(289)

• Company Name:Jiangxi Puxin Biotechnology Co., Ltd
• Tel:15867635987 15867635987
• Products Intro:Product Name:Neratinib
  CAS:698387-09-6
  Purity:99% Package:1kg
• CB Index:58
• Related Information:Catalog(286)

• Company Name:J & K SCIENTIFIC LTD.
• Tel:010-82848833 400-666-7788
• Products Intro:Product Name:Neratinib, 99%, a highly selective HER2 and EGFR inhibitor
  CAS:698387-09-6
  Purity:99% Package:10MG;250MG;50MG More...
• CB Index:76
• Related Information:Catalog(96815)

• Company Name:Chembest Research Laboratories Limited
• Tel:+86-21-20908456
• Products Intro:Product Name:Neratinib (HKI-272)
  CAS:698387-09-6
  Purity:98%+ Package:100mg;500mg;1g;5g;10g;50g;100g Remarks:C13927 More...
• CB Index:61
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• Company Name:Jia Xing Isenchem Co.,Ltd
• Tel:0573-85285100 18627885956
• Products Intro:CAS:698387-09-6
  Purity:98% (HPLC or GC) Package:25g,100g,500g;1kg More...
• CB Index:66
• Related Information:Catalog(9513)