Polyethylene-polypropylene glycol

• Product Name:Polyethylene-polypropylene glycol
• Synonyms: Polymerofmethyloxiraneandoxirane polyoxyethylene-oxy-propylene proxanoltsl-3 rc102 ucon75-h-1400 pluronic F-127 cell culture tested PLURONIC F-127, PROTEIN GRADEDetergent, 10% Solution pluronic F-68 plant cell culture tested
• CAS:9003-11-6
• MF:(C3H6O.C2H4O)x
• MW:102.1317
• EINECS:618-355-0
• Mol File:9003-11-6.mol
• 

<p><span style="font-size:13px">Polyethylene-polypropylene glycol</span> is a liquid surfactant polymer.</p> <p><span style="font-size:13px">Polyethylene-polypropylene glycol</span> generally occur as white, waxy, free-flowing prilled granules, or as cast solids. They are practically odorless and tasteless. At room temperature, poloxamer 124 occurs as a colorless liquid.</p> <p><span style="font-size:13px">Polyethylene-polypropylene glycol</span> is stable materials. Aqueous solutions are stable in the presence of acids, alkalis, and metal ions. However, aqueous solutions support mold growth.<br> The bulk material should be stored in a well-closed container in a cool, dry place.</p> <p><span style="font-size:13px">Polyethylene-polypropylene glycol</span> is used in a variety of oral, parenteral, and topical pharmaceutical formulations, and are generally regarded as nontoxic and nonirritant materials.<span style="font-size:13px">Polyethylene-polypropylene glycol is&nbsp;</span> not metabolized in the body.<br> Animal toxicity studies, with dogs and rabbits, have shown <span style="font-size:13px">Polyethylene-polypropylene glycol</span> to be nonirritating and nonsensitizing when applied in 5% w/v and 10% w/v concentration to the eyes, gums, and skin.<br> In a 14-day study of intravenous administration at concentrations up to 0.5 g/kg/day to rabbits, no overt adverse effects were noted. A similar study with dogs also showed no adverse effects at dosage levels up to 0.5 g/kg/day. In a longer-term study, rats fed 3% w/w or 5% w/w of poloxamer in food for up to 2 years did not exhibit any significant symptoms of toxicity. However, rats receiving 7.5% w/w of poloxamer in their diet showed some decrease in growth rate.<br> No hemolysis of human blood cells was observed over 18 hours at 25°C, with 0.001–10% w/v poloxamer solutions.<br> (mouse, IV): 1 g/kg<br> (mouse, oral): 15 g/kg<br> (mouse, SC): 5.5 g/kg<br> (rat, IV): 7.5 g/kg<br> (rat, oral): 9.4 g/kg</p> <p><span style="font-size:13px">Polyethylene-polypropylene glycol is</span> nonionic polyoxyethylene–polyoxypropylene copolymers used primarily in pharmaceutical formulations as emulsifying or solubilizing agents.The polyoxyethylene segment is hydrophilic while the polyoxypropylene segment is hydrophobic. All of the <span style="font-size:13px">Polyethylene-polypropylene glycol</span> is chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides added during manufacture. Their physical and surface-active properties vary over a wide range and a number of different types are commercially available;<br> <span style="font-size:13px">Polyethylene-polypropylene glycol is&nbsp;</span> used as emulsifying agents in intravenous fat emulsions, and as solubilizing and stabilizing agents to maintain the clarity of elixirs and syrups. <span style="font-size:13px">Polyethylene-polypropylene glycol</span> may also be used as wetting agents; in ointments, suppository bases, and gels; and as tablet binders and coatings.<br> Poloxamer 188 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems. More recently,<span style="font-size:13px">Polyethylene-polypropylene glycol</span> has found use in drug-delivery systems.<br> Therapeutically, poloxamer 188 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; it is usually used in combination with a laxative such as danthron. <span style="font-size:13px">Polyethylene-polypropylene glycol</span> may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers.<br> Poloxamer 338 and 407 are used in solutions for contact lens care.</p> <p><span style="font-size:13px">Polyethylene-polypropylene glycol</span> is used in a variety of oral, parenteral, and topical pharmaceutical formulations, and are generally regarded as nontoxic and nonirritant materials.<span style="font-size:13px">Polyethylene-polypropylene glycol is&nbsp;</span> not metabolized in the body.<br> Animal toxicity studies, with dogs and rabbits, have shown <span style="font-size:13px">Polyethylene-polypropylene glycol</span> to be nonirritating and nonsensitizing when applied in 5% w/v and 10% w/v concentration to the eyes, gums, and skin.<br> In a 14-day study of intravenous administration at concentrations up to 0.5 g/kg/day to rabbits, no overt adverse effects were noted. A similar study with dogs also showed no adverse effects at dosage levels up to 0.5 g/kg/day. In a longer-term study, rats fed 3% w/w or 5% w/w of poloxamer in food for up to 2 years did not exhibit any significant symptoms of toxicity. However, rats receiving 7.5% w/w of poloxamer in their diet showed some decrease in growth rate.<br> No hemolysis of human blood cells was observed over 18 hours at 25°C, with 0.001–10% w/v poloxamer solutions.<br> (mouse, IV): 1 g/kg<br> (mouse, oral): 15 g/kg<br> (mouse, SC): 5.5 g/kg<br> (rat, IV): 7.5 g/kg<br> (rat, oral): 9.4 g/kg</p>

• Polyethylene-polypropylene glycol
• 
• US $100.00-75.00/kg
• CAS:9003-11-6
• Min. Order: 1kg
• Purity: 99%
• Supply Ability: 5000
• 2024-11-17

• Poloxamer 407
• 
• US $0.00 /g
• CAS:9003-11-6
• Min. Order: 1g
• Purity: More Than 99%
• Supply Ability: 50kg/Month
• 2024-11-15

• Company Name:Wuhan Dingxintong Pharmaceutical Co. , Ltd.
• Tel:027-83984790 17720532645
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  Purity:P407巴斯夫原装90KG/桶，可以提供样品【原装正品】，提供13%增票 Package:1桶/RMB 20000
• CB Index:58
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• Tel:15337241005 13260682861
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• Tel:027-027-83305579 13697349395
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• Company Name:Shanghai Yikefan Biotechnology Co., LTD
• Tel:18221419461; 18221419461
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• Tel:029-19991803015 19991803015
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