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1374640-70-6

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1374640-70-6 Basic informationMore
USE
CO-1686 inhibited the p-EGFR in EGFR-expressing cells with an IC50 ranging from 62 to 187 nM while inhibiting EGFR phosphorylation. In three WT EGFR-expressing cells, the IC50 is larger than 2,000 nM. CO-1686 can selectively inhibit the growth of mutant EGFR expressing NSCLC cells with a GI50 ranging from 7 to 32 nM while inducing apoptosis. The CO-1686-resistant NSCLC cell line exhibited a signal for epithelial-mesenchymal transition and increased susceptibility to AKT inhibitors.
Lastest Price from CO-1686 manufacturers
  • CO-1686
  • US $7.00 /KG
  • CAS: 1374640-70-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000KG
  • 2019-07-06

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