BMN 673

• Product Name:BMN 673
• Synonyms: BMN 673 LT-673 (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazine-3-one (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-Methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one Talazoparib 3H-Pyrido[4,3,2-de]phthalazin-3-one, 5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-, (8S,9R)- Talazoparib (BMN 673) (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazine-3-one BMN673
• CAS:1207456-01-6
• MF:C19H14F2N6O
• MW:380.35
• EINECS:
• Mol File:1207456-01-6.mol
• 

BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. BMN 673 selectively kills cancer cells with BRCA-1 or BRCA-2 mutations. BMN 673 demonstrates single-agent cytotoxicityin BRCA-1 mutant (MX-1, IC50 = 0.3 nM) and BRCA-2 mutant cells (Capan-1, IC50 = 5 nM). In contrast, in MRC-5 normal human fibroblastand other tumor cell lines with wild-type BRCA-1 and BRCA-2 genes, IC50 of BMN 673 ranges between 90 nM and 1.9 μM. In cultured human cancer cells, BMN 673 also significantly enhances the cytotoxic efficacy of both Temozolomide and SN-38. Off-target molecular screening did not identify significant non-specific activity for this class of PARP inhibitors.

• BMN673/Talazoparib
• 
• US $0.00-0.00/kg
• CAS:1207456-01-6
• Min. Order: 1kg
• Purity: 99%, Single impurity＜0.1
• Supply Ability: 1 ton
• 2023-12-23

• Talazoparib
• 
• US $15.00-10.00/KG
• CAS:1207456-01-6
• Min. Order: 1KG
• Purity: 99%+ HPLC
• Supply Ability: Monthly supply of 1 ton
• 2021-07-13

• Company Name:Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd.
• Tel: 13771642864
• Products Intro:Product Name:BMN673/Talazoparib
  CAS:1207456-01-6
  Purity:98+% Package:1g;5g;10g;100g;1kg;10kg More...
• CB Index:58
• Related Information:Catalog(1027)

• Company Name:Chembest Research Laboratories Limited
• Tel:021-20908456
• Products Intro:Product Name:Talazoparib (BMN 673)
  CAS:1207456-01-6
  Purity:98%+ HPLC Package:50mg;100mg;500mg;1g;5g;10g Remarks:Biochemical Reagents; Pharmaceutical Intermediates More...
• CB Index:61
• Related Information:Catalog(6011)

• Company Name:Dalian Meilun Biotech Co., Ltd.
• Tel:0411-62910999 13889544652
• Products Intro:Product Name:BMN 673
  CAS:1207456-01-6
  Purity:>98% Package:10MG Remarks:6800 More...
• CB Index:58
• Related Information:Catalog(4647)

• Company Name:Shanghai Topbiochem Technology Co., Ltd
• Tel:021-58170097
• Products Intro:Product Name:(8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazine-3-one
  CAS:1207456-01-6
  Purity:98% Package:25g;100g;500g;1kg
• CB Index:58
• Related Information:Catalog(9442)