BMN 673
1207456-01-6 Basic informationMore
- Product Name:BMN 673
- Synonyms: BMN 673 LT-673 (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazine-3-one (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-Methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one Talazoparib 3H-Pyrido[4,3,2-de]phthalazin-3-one, 5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-, (8S,9R)- Talazoparib (BMN 673) (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazine-3-one BMN673
- CAS:1207456-01-6
- MF:C19H14F2N6O
- MW:380.35
- EINECS:
- Mol File:1207456-01-6.mol
-
USE
BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. BMN 673 selectively kills cancer cells with BRCA-1 or BRCA-2 mutations. BMN 673 demonstrates single-agent cytotoxicityin BRCA-1 mutant (MX-1, IC50 = 0.3 nM) and BRCA-2 mutant cells (Capan-1, IC50 = 5 nM). In contrast, in MRC-5 normal human fibroblastand other tumor cell lines with wild-type BRCA-1 and BRCA-2 genes, IC50 of BMN 673 ranges between 90 nM and 1.9 μM. In cultured human cancer cells, BMN 673 also significantly enhances the cytotoxic efficacy of both Temozolomide and SN-38. Off-target molecular screening did not identify significant non-specific activity for this class of PARP inhibitors.
Lastest Price from BMN 673 manufacturers
- BMN673/Talazoparib
-
- US $0.00-0.00/kg
- CAS:1207456-01-6
- Min. Order: 1kg
- Purity: 99%, Single impurity＜0.1
- Supply Ability: 1 ton
- 2024-11-26
- Talazoparib
-
- US $15.00-10.00/KG
- CAS:1207456-01-6
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 2021-07-13
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- Company Name:Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd.
- Tel: 13771642864
- Products Intro:Product Name:BMN673/Talazoparib
CAS:1207456-01-6
Purity:98+% Package:1g;5g;10g;100g;1kg;10kg More... - CB Index:58
- Related Information:Catalog(1112)
- Company Name:RD International Technology Co., Limited
- Tel: 18024082417
- Products Intro:Product Name:Talazoparib
CAS:1207456-01-6
Purity:0.98 Package:5mg;10mg;50mg;100mg;250mg;500mg;1g Remarks:g - CB Index:58
- Related Information:Catalog(9266)
- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:Talazoparib (BMN 673)
CAS:1207456-01-6
Purity:98%+ HPLC Package:50mg;100mg;500mg;1g;5g;10g Remarks:Biochemical Reagents; Pharmaceutical Intermediates More... - CB Index:61
- Related Information:Catalog(6005)
- Company Name:Dalian Meilun Biotech Co., Ltd.
- Tel:0411-62910999 13889544652
- Products Intro:Product Name:BMN 673
CAS:1207456-01-6
Purity:>98% Package:10MG Remarks:6800 More... - CB Index:58
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- Company Name:Shanghai Topbiochem Technology Co., Ltd
- Tel:021-58170097
- Products Intro:Product Name:(8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazine-3-one
CAS:1207456-01-6
Purity:98% Package:25g;100g;500g;1kg - CB Index:58
- Related Information:Catalog(9458)