Dacomitinib (PF299804)
1110813-31-4 Basic informationMore
- Product Name:Dacomitinib (PF299804)
- Synonyms: PF-00299804-03 PF-00299804 DacoMitinib (PF-00299804) DacoMitinib,PF299804 DacoMitinib (PF299804,PF-00299804) PF299804;DACOMITINIB DacoMitinib (PF299804, PF299) (E)-N-(4-((3-chloro-4-fluorophenyl)aMino)-7-Methoxyquizolin-6-yl)-4-(piperidin-1-yl)but-2-eMide
- CAS:1110813-31-4
- MF:C24H25ClFN5O2
- MW:469.94
- EINECS:000-000-0
- Mol File:1110813-31-4.mol
-
USE
Dacomitibib (Dacomitinib, PF299804) is an effective and irreversible pan-ErbB inhibitor that is most effective in EGFR, with an IC50 of 6 nM. It is also highly effective in NSCLCs that carries EGFR or ERBB2 mutants (against Gefitinib) and EGFR T790M mutant. Phase 2.<br />
Dacomitinib is taken orally once-daily. It is an irreversible inhibitor of HER-1 (EGFR), HER-2 and HER-4 tyrosine kinases. Dacomitinib targets multiple receptors of the HER pathway, whereas currently marketed HER-1 (EGFR) inhibitors for non-small cell lung cancer (NSCLC) target only one receptor in this pathway,developed by Pfizer.
Lastest Price from Dacomitinib (PF299804) manufacturers
- Dacomitinib
-
- US $0.00 /g
- CAS:1110813-31-4
- Min. Order: 1g
- Purity: 98% HPLC
- Supply Ability: 1kg
- 2024-03-12
- Dacomitinib (PF299804)
-
- US $60.00-600.00/kg
- CAS:1110813-31-4
- Min. Order: 10kg
- Purity: 0.99
- Supply Ability: 20tons
- 2024-01-02
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- Company Name:WuHu Linze pharmaceutical Co.,Ltd.
- Tel:0553-0553-5802116 18356571950
- Products Intro:Product Name:Dacomitinib (PF299804)
CAS:1110813-31-4
Purity:99.9 Package:500g More... - CB Index:58
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- Company Name:Chembest Research Laboratories Limited
- Tel:021-20908456
- Products Intro:Product Name:Dacomitinib (PF-299804
CAS:1110813-31-4
Purity:98%+ HPLC Package:50mg;100mg;500mg;1g;5g;10g Remarks:Biochemical Reagents; Pharmaceutical Intermediates More... - CB Index:61
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- Company Name:TCI (Shanghai) Development Co., Ltd.
- Tel:021-67121386
- Products Intro:Product Name:Dacomitinib
CAS:1110813-31-4
Purity:98.0% LC Package:250MG,50MG More... - CB Index:81
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- Company Name:Adamas Reagent, Ltd.
- Tel:400-6009262 16621234537
- Products Intro:Product Name:Dacomitinib
CAS:1110813-31-4
Purity:99%+ Package:100mg;250mg;1g;5g - CB Index:59
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