Propafenone
54063-53-5 Basic informationMore
- Product Name:Propafenone
- Synonyms: WZ-884-643 β-Phenyl-2'-[3-(propylamino)-2-hydroxypropoxy]propiophenone C07381 5-OH-Propafenone-D5 N-(carboxypheny)guanidine hydrochloride 1-(2-(2-Hydroxy-3-(propylamino) -3-phenylpropan-1-one 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone
- CAS:54063-53-5
- MF:C21H27NO3
- MW:341.44
- EINECS:258-955-6
- Mol File:54063-53-5.mol
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USE
Propafenone, 2-[2＇-hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone (Rythmol), a classIC antiarrhythmic drug, contains a chiral center and is marketedas the racemic mixture. Therapy with the racemicmixture of propafenone produces effects that can be attributedto both (S) and (R) enantiomers. Although (R) and (S)enantiomers exert similarNa<sup>+</sup>channel–blocking effects, the(S) enantiomer also produces aβ-adrenergic blockade. As aresult, the (S) enantiomer is reported to be 40-fold morepotent than the (R) enantiomer as an antiarrhythmic agent.The enantiomers also display stereoselective dispositioncharacteristics. The (R) enantiomer is cleared more quickly.Hepatic metabolism is polymorphic and determined genetically.Ten percent of Caucasians have a reduced capacity tohydroxylate the drug to form 5-hydroxypropafenone. Thispolymorphic metabolism accounts for the interindividualvariability in the relationships between dose and concentrationand, thus, variability in the pharmacodynamic effects ofthe drug. The 5-hydroxy metabolites of both enantiomersare as potent as the parent compound in blocking Na<sup>+</sup>channels.Propafenone also depresses the slow inward current ofCa2<sup>+</sup>ions.
Lastest Price from Propafenone manufacturers
- Propafenone
-
- US $0.00-0.00/kg
- CAS:54063-53-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20tons
- 2024-11-13
- Propafenone
-
- US $0.00 /KG
- CAS:54063-53-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500kg/month
- 2024-11-12
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- Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
- Tel:021-61259108 18621169109
- Products Intro:Product Name:Propafenone
CAS:54063-53-5
Purity:99% Package:100g Remarks:B66070 More... - CB Index:62
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:Propafenone
CAS:54063-53-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
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- Company Name:Shanghai Longsheng chemical Co.,Ltd.
- Tel:021-58099652-8005 13585536065
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- Company Name:XiaoGan ShenYuan ChemPharm co,ltd
- Tel: 15527768850
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- Company Name:Hangzhou Yuhao Chemical Technology Co., Ltd
- Tel:0571-82693216
- Products Intro:Product Name:Propafenone HCl
CAS:54063-53-5
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- Company Name:Wuhan Fortuna Chemical Co., Ltd
- Tel:027-59207852 13308628970
- Products Intro:Product Name:Propafenone Hydrochloride
Purity:99% Package:1kg，25kg More... - CB Index:58
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