3-hydroxyphenazepam
70030-11-4 Basic informationMore
- Product Name:3-hydroxyphenazepam
- Synonyms: 3-hydroxyphenazepam 2H-1,4-Benzodiazepin-2-one, 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy- 7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one 3-Hydroxyphenazepam CAS NO.70030-11-4
- CAS:70030-11-4
- MF:C15H10BrClN2O2
- MW:365.61
- EINECS:
- Mol File:70030-11-4.mol
USE
3-Hydroxyphenazepam, a metabolite of phenazepam, is also a GABAA receptor agonist. It has diminished myorelaxant properties, but is about equivalent in most other regards.Like other benzodiazepines, 3-hydroxyphenazepam behaves as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor with an EC50 value of 10.3 nM. 3-hydroxyphenazepam is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety.
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