Trastuzumab
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- Product Name:Trastuzumab
- Synonyms: Trastuzumab
- CAS:
- MF:
- MW:0
- EINECS:
- Mol File:Mol File
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USE
Trastuzumab (Herceptin, humanized) is an MAb engineeredfrom the human epidermal growth factor receptor type 2(HER2) protein. This MAb is a human–murine immunoglobulin.It contains human structural domains (framework) andthe CDR of a murine antibody (4D5) that binds specifically toHER2. IgG1 κ is the type structure, and the antibody is monoclonal.The protein inhibits the proliferation of human tumorcells that overexpress HER2.<br/>Trastuzumab is indicated for use as a single agent for thetreatment of patients with metastatic breast cancer whose tumorsoverexpress the HER2 protein and who have not receivedchemotherapy for their metastatic disease.<br/>The HER2 proto-oncogene encodes a transmembrane receptorprotein of 185 kDa that is structurally related to theepidermal growth factor receptor HER2. Overexpression ofthis protein is observed in 25% to 30% of primary breastcancers. Trastuzumab binds with high affinity to the extracellulardomain of HER2. It inhibits the proliferation ofhuman tumor cells that overexpress HER2. Trastuzumabalso mediates the process of antibody-mediated cellular cytotoxicity(ADCC). This process, leading to cell death, ispreferentially exerted on HER2-overexpressing cancer cellsover those that do not overexpress HER2.
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- Company Name:Shanghai Hanjing Chemicals Co., Ltd.
- Tel:021-54285032 13641685631
- Products Intro:Product Name:Trastuzumab
Purity:99% Package:1G; 5G; 10G;100G;500G;1KG;10KG More... - CB Index:55
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- Company Name:Wuhan Chemstan Biotechnology Co., Ltd.
- Tel:027-65317797 15926423062
- Products Intro:Product Name:Trastuzumab
Purity:>95%;1mg/ml Package:200ug;500ug;1mg - CB Index:58
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- Company Name:Shanghai Han-Xiang Chemical Co., Ltd.
- Tel:+86 (21) 5027-2946, +86 13818785766
- Products Intro:Product Name:TRASTUZUMAB
- CB Index:50
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- Company Name:Shanghai Qiming Biological Technology Co., Ltd.
- Tel:021-61483491
- Products Intro:Product Name:Trastuzumab
- CB Index:58
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- Company Name:Shanghai Saimai Biological Technology Co., Ltd.
- Tel:021-68785630
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- CB Index:58
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- Company Name:Guangzhou Weijia Technology Co., Ltd.
- Tel:020-84224925 18300190102
- Products Intro:Product Name:Trastuzumab
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- Company Name:Beijing Baiao Laibo Technology Co., Ltd.
- Tel:010-56109559 18518407031
- Products Intro:Product Name:Trastuzumab
- CB Index:58
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